Toripalimab Plus Pemetrexed+Platinus in Advanced Non-small-cell Lungcancer Patients Previsouly Treated EGFR-TKI

Inclusion Criteria:

Only the patients meeting all the following criteria can be eligible to participate in the trial:

* Fully informed consent and signed ICF;
* Age of 18-75 years;
* Histologically and/or cytologically confirmed advanced or recurrent stage III B-C or IV (AJCC Version 8) NSCLC with TKI-resistant EGFR-mutated tumors, which also satisfy following conditions: Without T790M mutation in exon 20 after 1st or 2nd generation EGFR-TKI (eg, gefitinib, erlotinib, icotinib, afatinib,etc.) treatment failure;If with T790M mutation in exon 20 after 1st or 2nd generation EGFR-TKI (eg, gefitinib, erlotinib, icotinib, afatinib,etc.),participants are required to have osimertinib or other 3rd generation EGFR-TKI treatment failure prior to enrollment.Participants with osimertinib treatment failure as 1st line therapy (regardless of their EGFR T790M mutation status);Previous neoadjuvant/adjuvant chemotherapy is allowed, but the time interval between the last dose of chemotherapy and recurrence/metastasis must be at least 6 months.
* With at least one measurable disease per RECIST 1.1;
* Agree to provide formalin fixed tumor specimen after EGFR-TKI treatment failure or provide fresh biopsy tissue;
* ECOG performance status of 0-1;
* Life expectancy ≥ 3 months;
* Good organ function;
* Any adverse event resulting from prior treatment, surgery, or radiotherapy must return to grade 0 or 1 according to NCI-CTCAE v5.0, except for alopecia of any grade;
* Willing and able to follow protocol visits, treatment plans, laboratory tests and other study procedures;
* Women of childbearing potential must have negative serum pregnancy test within 3 days prior to the first dose of investigational product:

Exclusion Criteria:

* Exclusion of tumor histology or cytology confirmed the presence of small cell lung cancer components, or squamous cell carcinoma components of more than 10%;
* Combined with other driver mutations with known therapeutic drug, including but not limited to: ALK rearrangement, ROS1 mutation, BRAF600E mutation;
* Previous systematic chemotherapy for advanced NSCLC;
* Subjects with no measurable lesions;
* Subjects with cancer meningitis and spinal cord compression;
* Subjects with untreated central nervous system (CNS) tumor metastasis;
* Subjects were previously treated with an anti-PD-1, anti-PD-L1 or anti-CTLA-4 agent;
* Subjects with any active, known or suspected autoimmune disease;
* Subjects who are now participating in other clinical studies or the last dose of prior investigational drug was given in \< 4 weeks (or 5 half-lives) from the first investigational product administration of this study;
* Subjects who were expected to receive any other antitumor therapy (eg, other maintenance therapy for NSCLC, radiotherapy, and/or surgical excision);
* Subjects who received major surgery within 4 weeks prior to enrollment or were not fully recovered from prior surgery;
* Subjects with other malignancies requiring concurrent treatment;
* Subjects with grade II or above myocardial ischemia or myocardial infarction, or subjects with arrhythmia with poor control;
* Subjects with uncontrolled pleural/pericardial effusion, or with ascites requiring repeated drainage;
* Subjects with uncontrolled tumor-related pain;
* Subjects with severe allergic reactions to other monoclonal antibodies and subjects with severe allergic reactions to pemetrexed, platinum or its prophylaxis;
* Subjects with psychological disorder, alcohol alcoholism, drug abuse or drug dependency