Clinical trial · Observational
Correlation Between Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination
Correlation Between Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination: a Prospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A prospective cohort study at a Tertiary University Hospital. From January to December 2018, we enrolled women with the following criteria: abnormal uterine bleeding in post-menopause, endometrial thickening in pre-or post-menopause; tamoxifen usage. Patients underwent office hysteroscopy with a 5-mm continuous-flow hysteroscope and endometrial biopsies were taken using miniaturized instruments. Senior operators had to foresee histopathological diagnosis using a questionnaire. Histopathological examination was conducted to confirm the diagnosis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Hyperplasia | — | UNRESOLVED | — |
| Endometrial Neoplasms | Endometrial Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Office Hysteroscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- AUB in Post-Menopause
- description
- Abnormal Uterine Bleeding (AUB) in Post-Menopause
- interventionNames
- Procedure: Office Hysteroscopy
- label
- Endometrial Thickening in post-menopause
- description
- Ultrasonographic detection of Thickened Endometrium in post-menopause
- interventionNames
- Procedure: Office Hysteroscopy
- label
- Endometrial Thickening in pre-menopause
- description
- Ultrasonographic detection of Thickened Endometrium in pre-menopause
- interventionNames
- Procedure: Office Hysteroscopy
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * abnormal uterine bleeding in post-menopause * ultrasonographic detection of endometrial thickening in pre-menopause * ultrasonographic detection of endometrial thickening in post-menopause * follow-up after Tamoxifen-based therapy regimens Exclusion Criteria: * severe urinary symptoms * history of severe comorbidities (autoimmune disorders, chronic diseases and severe cardiac disease)
References
Publications (4)
- BACKGROUNDGhoubara A, Sundar S, Ewies AAA. Predictors of malignancy in endometrial polyps: study of 421 women with postmenopausal bleeding. Climacteric. 2018 Feb;21(1):82-87. doi: 10.1080/13697137.2017.1410783. Epub 2017 Dec 8. PMID 29219004
- BACKGROUNDTrimble CL, Kauderer J, Zaino R, Silverberg S, Lim PC, Burke JJ 2nd, Alberts D, Curtin J. Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer. 2006 Feb 15;106(4):812-9. doi: 10.1002/cncr.21650. PMID 16400639
- BACKGROUNDBourdel N, Chauvet P, Tognazza E, Pereira B, Botchorishvili R, Canis M. Sampling in Atypical Endometrial Hyperplasia: Which Method Results in the Lowest Underestimation of Endometrial Cancer? A Systematic Review and Meta-analysis. J Minim Invasive Gynecol. 2016 Jul-Aug;23(5):692-701. doi: 10.1016/j.jmig.2016.03.017. Epub 2016 Apr 4. PMID 27058769
- DERIVEDDe Franciscis P, Riemma G, Schiattarella A, Cobellis L, Guadagno M, Vitale SG, Mosca L, Cianci A, Colacurci N. Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination. Diagnostics (Basel). 2019 Oct 7;9(4):142. doi: 10.3390/diagnostics9040142. PMID 31591361