Clinical trial · Interventional
Suubi4Cancer: Improving Access to Pediatric Cancer Services and Treatment Adherence Among Children Living With HIV/AIDS
Suubi4Cancer: An Innovative Combination Intervention to Improve Access to Pediatric Cancer Services and Treatment Adherence Among Children Living With HIV/AIDS in Uganda
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): We implemented Aims 1 and 2, but did not have a sufficient sample size to carry out the clinical trial portion
Summary
Brief summary (as posted)
This study will tailor and explore the short-term preliminary outcomes of an existing evidence-based Economic Empowerment (EE) Intervention, Suubi (Hope in Luganda -local Ugandan language), on access to pediatric cancer diagnosis, care, and treatment adherence among youth living with HIV (YLWHIV) with suspected cancers. The study will specifically address the following aims/research questions: Aim 1. Identify confirmed and suspected cancer cases in a cohort of \>3000 HIV+ youth (ages 10-24) seen at 39 clinics in 5 districts heavily affected by HIV/AIDS in southern Uganda. Aim 2. Identify those lost to follow-up from the cohort in Aim 1 and determine reasons for loss to follow-up through qualitative interviews. 2.1. Identify those who have not returned to the clinic in ≥ 60 days (\~2 months) from their expected return visit date. 2.2. Determine reasons for loss to follow-up or death. Aim 3. Conduct an open clinical trial to establish the feasibility and acceptability of the Suubi4Cancer intervention. \*Due to insufficient sample size, Aim 3 is not implemented.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| HIV/AIDS | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Combination intervention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Combination intervention
- description
- Selected families will be assigned to the treatment condition (delivered over 9 months) to receive BSC plus a family EE intervention comprising of a matched family development account (FDA) for health-related expenses, including transport to UCI, food/nutrition, and health insurance. Combined with the Family EE will be four sessions of Financial Literacy and Management (FL\&M) and two sessions of cancer education. The sessions will be conducted over a 4-week period. The two cancer-specific education sessions will use UCI materials to address: 1) definitions of cancer, potential causes, signs and symptoms, and importance of cancer testing; 2) debunking cultural explanations for the causes of cancer and misconceptions (beliefs, values, norms and prevailing attitudes)regarding cancer that largely impede service use. \*Due to insufficient sample size, the open clinical trial is not being conducted.
- interventionNames
- Behavioral: Combination intervention
Primary outcomes (3)
- measure
- Cancer Treatment Access
- timeFrame
- Every assessment time point (Baseline and at 9-month post-intervention initiation)
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
- Maximum age
- 24 Years
Show eligibility criteria text
Inclusion Criteria: Youth inclusion criteria are: * HIV+ (confirmation by medical report) * Must be living within a family (defined broadly, not necessarily with biological parents); * Must be between 10-24 years old * Attending one of the 39 clinics * Did not access services or expressed unwillingness and/or inability to do so. * For Aim 1, inclusion criteria only includes 1) and 3). Caregiver inclusion criteria: * Have a YLWHIV (with suspected cancer) under their care who attends one of the 39 study-affiliated clinics. Exclusion Criteria: Potential participants will be excluded from the study if the research team determines that the participant: * Cannot comprehend the study and participant rights * Is unwilling to participate.
References
Publications (1)
- DERIVEDSsewamala FM, Sensoy Bahar O, Johnson KJ, Katumba RGN. Suubi4Cancer: A protocol for an innovative combination intervention to improve access to pediatric cancer services and treatment adherence among children living with HIV/AIDS in Uganda. Contemp Clin Trials Commun. 2019 Oct 1;16:100459. doi: 10.1016/j.conctc.2019.100459. eCollection 2019 Dec. PMID 31650077