Prognostic Factors in Prostate Cancer for Patients Treated by Watchful Waiting

The Trans-Atlantic Prostate Group (TAPG) was established to examine the hypothesis that through a detailed retrospective analysis of outcome in a group of men with clinically localised prostate cancer at diagnosis, variables such as biological, pathological and clinical markers, could be identified that might accurately predict the prognosis of clinically localised prostate cancer.

Sex

Male

Minimum age

18 Years

Maximum age

76 Years

Inclusion Criteria:

* Patients must be aged less than 76 years at the time of diagnosis
* Patients must have had a baseline serum PSA level measured before starting any treatment and within six months of diagnosis
* Patients must have been diagnosed between 1990 and 2006 with a clinically localized (clinical stage T1-T3, N0 or NX, MO or MX) prostate cancer, in the judgment of the treating physician
* The initial diagnostic biopsy sample must be available for review. Patients should have (but are not required to have) tissue blocks available for review.
* There must be no evidence of metastatic disease
* While data collection will include review of the reports of any imaging studies of the prostate, bones, or soft tissues, these studies are not essential
* Each patient should have had an adequate medical evaluation to document the status of disease for the first five years after diagnosis. Follow-up should include an annual PSA and digital rectal examination. Records will be reviewed to seek all information about medical evaluation after the time of diagnosis.

Exclusion Criteria:

* Patients older than 76 years at the time of diagnosis
* Patients who have not had a baseline serum PSA level measured before starting any treatment
* Patients who do not have the initial diagnosis biopsy sample for review
* Patients with evidence of metastatic disease

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