Clinical trial · Interventional
Utility of LDCT in Lung Cancer Screening in a TB Endemic Region
A Study Assessing the Utility of Low-dose Computed Tomography (LDCT) in Lung Cancer Screening in North India
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lung cancer screening with low-dose computed tomography (LDCT) has been recently shown to result in a significant reduction in lung cancer-specific mortality. However, the utility of LDCT screening in developing countries with high incidence of tuberculosis has not been adequately studied. The investigators hypothesize that LDCT screening in tuberculosis endemic regions is likely to yield a large proportion of false-positive results, especially in the initial round of screening, posing a significant burden on the healthcare system. Herein, the investigators assess the utility of LDCT and its cost-effectiveness in India.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low-dose computed tomography of chest | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- LDCT arm
- description
- All eligible participants will undergo screening with LDCT
- interventionNames
- Diagnostic Test: Low-dose computed tomography of chest
Primary outcomes (1)
- measure
- Positivity rate with LDCT screening
- timeFrame
- After baseline LDCT scan results are available (an average of 1 week after LDCT scan)
- description
- The proportion of participants with a positive result among the total number of individuals screened with LDCT
Secondary outcomes (7)
- measure
- Rate of detection of lung cancer
- timeFrame
- Up to 6 months after the LDCT scan
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: * Individuals aged 55-74 years with at least 30 pack-year history of smoking (or smoking index ≥600) who are current smokers or quit within the last 15 years OR * Individuals aged 50-74 years with at least 20 pack-year history of smoking (or smoking index ≥400) who are current or former smokers with COPD or family history of lung cancer in any first-degree relative Exclusion Criteria: * Symptomatic structural lung disease other than COPD (e.g. bronchiectasis, chronic pulmonary aspergillosis, pulmonary fibrosis) * Severe comorbid condition which is likely to limit the survival of the patient in the opinion of the investigator (e.g. advanced lung disease, cardiovascular disease, chronic kidney disease, chronic liver disease) * Presence of symptoms which lead to a suspicion of lung cancer (e.g. hemoptysis or unexplained weight loss \[\>5 kg\] within the last 6 months) * Conditions which may interfere interpretation of CT (e.g. metallic implants on chest wall, cardiac pacemakers) * Treatment for any other cancer in the last 5 years * Pulmonary infection (for which treatment with antimicrobials is indicated) which is active at present or was recent (within the last 3 months) * Patients who have underwent CT chest within the last 18 months * Negative consent
References
Publications (0)
Data not yet available