HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies

Inclusion Criteria:

* Diagnosis of a solid malignancy, stage I-IV.
* Planned surgical resection or biopsy of a malignancy
* ECOG 0 or 1
* Estimated life expectancy \> 3 months
* Age ≥ 18 years
* Adequate hematologic function, with WBC ≥ 3000/microliter, hemoglobin ≥ 9 g/dL (it is acceptable to have had prior transfusion), platelets ≥ 75,000/microliter; PT-INR \<1.5, PTT \<1.5X ULN
* Adequate renal and hepatic function, with serum creatinine \< 1.5 mg/dL, bilirubin \< 1.5 mg/dL (except for Gilbert's syndrome which will allow bilirubin ≤ 2.0 mg/dL), ALT and AST ≤ 2.5 x upper limit of normal or if liver metastases are present \< 5 x upper limit of normal.
* Female patients must be of non-child-bearing potential or use effective contraception
* Ability to understand and provide signed informed consent that fulfills Institutional Review Board's guidelines.
* Ability to return to Duke University Medical Center for adequate follow-up, as required by this protocol.

Exclusion Criteria:

* Serious chronic or acute illness considered by the P.I. to constitute an unwarranted high risk for investigational drug treatment.
* Patients with porphyria or a known hypersensitivity to any component of this preparation are excluded.
* Medical or psychological impediment to probable compliance with the protocol.
* Asthma under medical management
* Uncontrolled high blood pressure
* Presence of a known active acute or chronic infection including HIV or viral hepatitis (Hepatitis B and C)).
* Pregnant or nursing women