Clinical trial · Interventional
Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriate UVB response. Ongoing studies have tested the ability of fractionated laser resurfacing (FLR) to assess how long this wounding effect lasts-and have found that this appears to be a durable response which lasts for at least two years. The findings that FLR protects geriatric skin at two years is the impetus for this study. This study is an interventional study to assess if FLR treatment of one forearm of geriatric subjects with multiple actinic keratosis will result in the short-term removal of actinic keratosis, and the long-term decrease in levels of future actinic keratosis and other non-melanoma skin cancers in comparison to the untreated arm. Study length and visit: The first part of the study is completed in 1 day then there are follow up visits at 90 days and every 6 months for 5 years.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Actinic Keratoses | — | UNRESOLVED | — |
| Aging | — | UNRESOLVED | — |
| Non-Melanoma Skin Cancer | Skin Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fractionated Laser Resurfacing | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Factionated Laser Resurfacing - Right Arm
- description
- Right forearm treatment of fractionated laser resurfacing.
- interventionNames
- Device: Fractionated Laser Resurfacing
- type
- EXPERIMENTAL
- label
- Factionated Laser Resurfacing - Left Arm
- description
- Left forearm treatment of fractionated laser resurfacing.
- interventionNames
- Device: Fractionated Laser Resurfacing
Primary outcomes (2)
- measure
- Change From Baseline in the Number of Actinic Keratosis due to FLR treatment.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with Actinic Keratosis within the past 6 months * At least 60 years of age, or older * Ability to comprehend procedures and risks versus benefits * Able to provide Informed Consent * Fair Skin (Fitzpatrick Type I or II) * Possess both Right and Left Forearms Exclusion Criteria: * Uncontrolled Diabetes Mellitus * Not able to comprehend procedures or risks versus benefits * Pregnant or nursing * Large tattoos on forearms * History of abnormal healing or scarring (i.e., keloids) * Any disease that gets worse while in the sun * Use of topical or oral anti-inflammatory medication or steroids * Allergy to lidocaine * Current use of photosensitizing medication
References
Publications (2)
- DERIVEDSpandau DF, Chen R, Wargo JJ, Rohan CA, Southern D, Zhang A, Loesch M, Weyerbacher J, Tholpady SS, Lewis DA, Kuhar M, Tsai KY, Castellanos AJ, Kemp MG, Markey M, Cates E, Williams AR, Knisely C, Bashir S, Gabbard R, Hoopes R, Travers JB. Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia. J Clin Invest. 2021 Oct 1;131(19):e150972. doi: 10.1172/JCI150972. PMID 34428179
- DERIVEDChen R, Wargo JJ, Williams A, Cates E, Spandau DF, Knisely C, Travers JB. Single Ablative Fractional Resurfacing Laser Treatment For Forearm Actinic Keratoses: 6-Month Follow-Up Data From An Intrapatient Comparison Between Treated and Untreated Sites. Lasers Surg Med. 2020 Jan;52(1):84-87. doi: 10.1002/lsm.23175. Epub 2019 Nov 17. PMID 31736123