Clinical trial · Interventional
The Value of Myomectomy in Women With Intramural Myoma Before IVF.
The Value of Myomectomy in Women With Intramural Myoma Before IVF. A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Women with intramural myoma not reaching the endometrial cavity will be randomized to either open myomectomy or no intervention . The participants will be assessed through full history-taking with special consideration to age and the duration, type, and cause of infertility. The medical examination included general, abdominal, and vaginal examinations. Finally, an ultrasonography examination was performed to check for the presence of three or more preantral follicles and to exclude ovarian cysts. On day 3 of a natural cycle, a baseline levels of FSH, luteinizing hormone (LH), , estradiol and anti-Müllerian hormone (AMH).Ovarian stimulation was performed using a long, antagonist, or short protocol. They were assigned to one of the 2 groups according to having an intramural myoma not indenting the cavity or not. All will be followed up by transvaginal ultrasonography . When two or more follicles had reached a mean diameter of 18 mm, oocyte maturation was triggered by intramuscular administration of hCG. Embryo transfer will be done at day 2, 3 or 5 according to the circumstances.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fibroid Uterus | Uterine Corpus Leiomyoma | ALIAS | 0.90 |
| IVF | — | UNRESOLVED | — |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Embryo transfer | Procedure | — | UNRESOLVED |
| Gonadotropins | Drug | — | UNRESOLVED |
| Human chorionic gonadotropin | Drug | — | UNRESOLVED |
| Open myomectomy | Procedure | — | UNRESOLVED |
| Ovum pick up | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Myomectomy group
- description
- women with intramural myoma not reaching endometrial cavity will undergo open myomectomy followed by ovarian stimulation for in vitro fertilization 6 months after the operation
- interventionNames
- Procedure: Open myomectomy
- Drug: Gonadotropins
- Drug: Human chorionic gonadotropin
- Procedure: Ovum pick up
- Procedure: Embryo transfer
- type
- ACTIVE_COMPARATOR
- label
- Conservative group
- description
- women with intramural myoma not reaching endometrial cavity will undergo ovarian stimulation for in vitro fertilization
- interventionNames
- Drug: Gonadotropins
- Drug: Human chorionic gonadotropin
- Procedure: Ovum pick up
- Procedure: Embryo transfer
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * • age younger than 40 years * FSH) less than 10 IU/L * serum prolactin level normal * uterine cavity abnormality was excluded by hysteroscopy or hysterosalpingography Exclusion Criteria: * abnormal endocrine function (e.g. abnormal thyroid or adrenal function) * ovarian cysts, * hydrosalpinx * endometrial polyps * male partner with azoospermia * ICSI performed for preimplantation genetic diagnosis.
References
Publications (0)
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