Clinical trial · Interventional

Cancer Survivors Acute Exercise Response 1

Immune and Skeletal Muscle Response to an Exercise Session in Cancer Survivors

NCT03903848CI-TRIAL-00037926unknownN/AClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

The aims of this study examine the immune system, muscle metabolism, and autonomic nervous system response to an acute bout of exercise. Cancer survivors will participate in an acute bout of exercise. Blood samples will be collected before the exercise bout and at two time points after the exercise bout to assess the proposed variables.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Neoplasms Malignant	Malignant Neoplasm	ALIAS	0.90

Interventions

Interventions (1)

Intervention	Type	Mapped drug	Match
Exercise	Other	—	UNRESOLVED

Design

Arms and outcomes

Arms (1)

type
EXPERIMENTAL
label
Exercise session
description
One session of physical exercise
interventionNames
1. Other: Exercise

Primary outcomes (4)

measure
Exercise-induced response of circulating monocytes
timeFrame
Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise
description
Circulating serum monocyte phenotype before and after one exercise session
measure
Exercise-induced response of circulating T cells
timeFrame
Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 40 Years
Maximum age: 70 Years

Show eligibility criteria text

Inclusion Criteria:

* Between the ages of 40-70 years

  * At least two years past detectible cancer (two years disease-free survival)
  * Have received chemotherapy and/or radiation as part of their cancer treatment
  * All cancers were of the organs/non-blood producing tissues (not blood/hematologic cancers) and while they were an adult (no history of pediatric cancer)
  * Meeting ACSM-AHA guidelines for exercise (150 minutes per week of cardiorespiratory fitness type exercises and \~two days per week of resistance training), as confirmed by a combination of a physical activity questionnaire and a cardiorespiratory fitness classification of "good" or higher (age and sex matched)
  * A BMI between 20-33 kg·m-2
  * Able to speak and read English

Exclusion Criteria:

Participants may not:

* Have any contraindications to moderate to vigorous exercise
* Have any recent illness or have been instructed not to exercise by a healthcare provider
* Participants may not have range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory)
* Be taking medications (prescription or over the counter) known to influence immune function (including daily NSAID's and beta blockers), cholesterol-lowering medications (statins), drugs that increase bone mass (bisphosphonates), or steroids.
* Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported).
* Be pregnant
* Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study)
* Fall outside of a BMI range of (20 - 33)
* Consume alcohol or recreational drugs for 24h prior to visits
* Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 2-3 times over the course of the study

References

Publications (0)

Data not yet available

No reference posted for this study.