Clinical trial · Interventional
Can Interval Walking Influence on Fatigue in the Danish Cohort of Myasthenia Gravis Patients
Physical Activity and Fatigue in Danish Patients With Myasthenia Gravis - an Intervention Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Due to restricted and new rules for data protection, the use of an app could not be approved
Summary
Brief summary (as posted)
The study is a controlled, randomized intervention trial. Patients are randomized into either an intervention group or a control group. The duration of the study is 10 weeks. Patients in the intervention group participate in a 10 weeks exercise program consisting of 150 minutes interval walking per week administered by an app on the patient's telephone. Patients in the control group live as usually, with a maximum of 30 minutes aerobic exercise per week. Before and after the 10 weeks study period, patients (from both the intervention and the control group) participate in a 2 hours session of functional testing (e.g. walk tests, test of muscle strength ect.) at Rigshospitalet.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Myasthenia Gravis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Interval walking | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Interval walking
- description
- Interval walking for 10 weeks, 150 minutes per week administered by an app on the patient's telephone.
- interventionNames
- Behavioral: Interval walking
- type
- NO_INTERVENTION
- label
- Control
- description
- Patients live as normal, though aerobe training restricted to a maximum of 30 minutes a week.
Primary outcomes (1)
- measure
- 6 minutes walk test
- timeFrame
- 6 minutes
- description
- Walk test
Secondary outcomes (6)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Able to provide signed informed consent. * Able to read and understand Danish or English. * Diagnosed with mild to moderate myasthenia gravis (I-IV on the Myasthenia Gravis Foundation of American Clinical Classification, MGFA). * Documented history of acetylcholine receptor (AChR) or Muscle Specific Kinase (MuSK) antibody positive, or abnormal repetitive nerve stimulation testing (decrement \> 10%) on EMG or abnormal single fiber EMG (conduction block or jitter) or based on their clinical history and symptom improvement with acethylcholinesterase inhibitors. * If the patient is on oral corticosteroids, the dose must be stable for at least 1 month prior to inclusion. * If the patient is on cholinesterase inhibitors the dose must be stable 2 weeks prior to inclusion. Exclusion Criteria: * MGFA grade V disease * Other disorders that are not related to MG, or drugs, that interfere with muscle strength, balance and fatigue. * Serious medical illness (e.g. uncontrolled insulin dependent diabetes mellitus, symptomatic coronary artery disease, and cancer). * Dementia or pregnancy. * Unspecified reasons judged by the investigator.
References
Publications (0)
Data not yet available