Clinical trial · Interventional
Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer
Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer: A Prospective Randomized Trial
NCT03900104CI-TRIAL-00043539completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators think that trans-cervical endometrial tracer injection will cause more paraaortic sentinel lymph node detection. Also, this application is easy, cost-effective and safer than hysteroscopic method. Transtubal tumor spearing will not occur with this method.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
| Sentinel Lymph Node | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cervical injection of technetium 99 m-labeled human albumin colloid particles | Procedure | — | UNRESOLVED |
| Transcervical endometrial injection of technetium 99 m-labeled human albumin colloid particles | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Transcervical endometrial injection arm
- description
- Tracer injection performed by a transcervical catheter in endometrial cancer patients.
- interventionNames
- Procedure: Transcervical endometrial injection of technetium 99 m-labeled human albumin colloid particles
- type
- ACTIVE_COMPARATOR
- label
- Cervical injection arm
- description
- Tracer injection was administered via the cervical route in endometrial cancer patients.
- interventionNames
- Procedure: Cervical injection of technetium 99 m-labeled human albumin colloid particles
Primary outcomes (1)
- measure
- Detected pelvic and paraaortic sentinel lymph node numbers
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Endometrial Cancer Patients * Suitable patients for surgical staging Exclusion Criteria: * Patients who cannot undergo cervical or transcervical endometrial injection * Pathology did not confirm endometrial cancer * Sarcoma of the uterine corpus * If a 90-day follow-up was not feasible
References
Publications (2)
- BACKGROUNDSolima E, Martinelli F, Ditto A, Maccauro M, Carcangiu M, Mariani L, Kusamura S, Fontanelli R, Grijuela B, Raspagliesi F. Diagnostic accuracy of sentinel node in endometrial cancer by using hysteroscopic injection of radiolabeled tracer. Gynecol Oncol. 2012 Sep;126(3):419-23. doi: 10.1016/j.ygyno.2012.05.025. Epub 2012 May 30. PMID 22659192
- BACKGROUNDNiikura H, Kaiho-Sakuma M, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, Takano T, Watanabe M, Ito K, Yaegashi N. Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol. 2013 Nov;131(2):299-303. doi: 10.1016/j.ygyno.2013.08.018. Epub 2013 Aug 27. PMID 23988415