Clinical trial · Observational
Persistent Cervical HPV Infection With Clearance and Vaginal Microbiota
Clinical Study on the Relationship Between Persistent Cervical HPV Infection With Clearance and Vaginal Microbial Community
NCT03895866CI-TRIAL-00040325unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the persistence infection and clearance of HPV infection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HPV-Related Squamous Cell Carcinoma | Human Papillomavirus-Related Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| The participants were assigned to different groups according to the results of HPV detection. | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Group A
- description
- High-risk HPV persistent infection more than half a year and reversion
- interventionNames
- Other: The participants were assigned to different groups according to the results of HPV detection.
- label
- Group B
- description
- High-risk HPV non-infection
- interventionNames
- Other: The participants were assigned to different groups according to the results of HPV detection.
Primary outcomes (1)
- measure
- The relationship between diversity of vaginal microbiota and HR-HPV persistent infection
- timeFrame
- 12 months
- description
- The persistent specific vaginal organism in HPV persistent infection women
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Those are aged 20 to 45 years old, have had vaginal intercourse more than 3 years, and aren't in menstrual, pregnancy or puerperium period. Exclusion Criteria: * Those have no vaginal intercourse, and can't cooperate the examiner. Women who are HIV or hepatitis B/C positive, have autoimmune disorders and systemic disease (like diabetes mellitus, hormone treatment diseases, severe liver and kidney dysfunction), or have severe mental illness and malignant tumors are also excluded. At the same time, all the participants should meet the following requirements: no vagina douching within last 2 days, no vaginal intercourse within last 3 days, no systemic application of antifungal agents or antibiotics or pessaries within last 14 days of sampling.
References
Publications (0)
Data not yet available
No reference posted for this study.