Clinical trial · Observational
Ultrasound-Guided Diaphragmatic Thickness Assessment as an Indicator of Successful Extubation in Mechanically Ventilated
Ultrasound-Guided Diaphragmatic Thickness Assessment as an Indicator of Successful Extubation in Mechanically Ventilated Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Weaning of mechanically ventilated patient is a daily challenge in Intensive Care units. Several indexes have been employed to assess the patient's ability to recover efficient spontaneous breathing. As the diaphragm is the main respiratory muscle, direct measurement of diaphragmatic function as predictors of extubation success or failure have not been extensively evaluated. Ultrasound can easily access diaphragm thickness (tdi) in its zone of apposition during, tdi can represent the contractile activity of the diaphragm and the efficiency of its function.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Successful Weaning | — | UNRESOLVED | — |
| Weaning Failure | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ultrasound assessment of diaphragm thickness in B-mode | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Sensitivity and specificity of diaphragm thickness compared to ABG as standard for weaning
- timeFrame
- 6 months
- description
- diagnostic accuracy of diaphragm thickness to predict weaning compared to ABG
- measure
- Sensitivity and specificity of diaphragm delta tdi compared to ABG as standard for weaning
- timeFrame
- 6 months
- description
- diagnostic accuracy of diaphragm delta tdi to predict weaning compared to ABG
Secondary outcomes (1)
- measure
- Sensitivity and specificity of RSBI compared to ABG as gold standard for weaning
- timeFrame
- 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age18-65 years. * ASA class 1 to 3, * body mass index (BMI) between 20 and 40 kg/m2 * intubation for ≥ 48 hours * Types of abdominal cancer surgery included partial gastrectomy, hysterectomy, Splenectomy, hepatectomy, and colectomy. Exclusion Criteria: * Hemodynamic instability requiring vasopressors. * Gas exchange impairment requiring positive end-expiratory pressure (PEEP) \>10 cmH2O and/or FIO2 \> 50% to obtain a PaO2 \> 60 mmHg. * Pressure support (PS) level \> 20 cmH2O. * Body temperature \> 38°C or \< 35°C. * Deep sedation state (RASS score \< -1). * History of chronic obstructive pulmonary disease, neuromuscular disease, anatomical malformation of the diaphragm, or use of muscle paralyzing agents, aminoglycosides and corticosteroids. * Pneumothorax or pneumomediastinum, increase intrabdominal pressure.
References
Publications (0)
Data not yet available