Clinical trial · Interventional
Dynamic Contrast Enhanced Computed Tomography to Assess Radiation Therapy in Liver Cancer Patients
Pilot Study of Dynamic Contrast Enhanced Computed Tomography (DCE-CT) Imaging for the Assessment of Radiation Therapy Outcome for Liver Cancer Patients
NCT03891654CI-TRIAL-00058172completedEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a pilot study that uses a standard of care technique, Stereotactic Body Radiation Therapy (SBRT), in combination with Dynamic Contrast Enhanced Computed Tomography (DCE-CT) to determine if perfusion changes from SBRT of liver cancer may be used for outcome assessment and prediction of prognosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dynamic Contrast Enhanced Computed Tomography | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Dynamic Contrast Enhanced Computed Tomography
- description
- DCE-CT, also known as perfusion CT, is a functional imaging modality that uses repeated computed tomography imaging after injection of an iodine based contrast agent.
- interventionNames
- Diagnostic Test: Dynamic Contrast Enhanced Computed Tomography
Primary outcomes (3)
- measure
- DCE-CT Perfusion Metrics: K-Trans
- timeFrame
- Baseline to end of follow-up, up to 12 weeks
- description
- Determine the association between the delivered radiation therapy dose distribution and the change in perfusion measurement through K-Trans (extraction-flow product) as shown through DCE-CT imaging.
- measure
- DCE-CT Perfusion Metrics: Blood Volume
- timeFrame
- Baseline to end of follow-up, up to 12 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: 1. Provision to sign and date the consent form 2. Stated willingness to comply with all study procedures and be available for the duration of the study 3. Be a Male or Female aged 18-100 4. Diagnosed with Liver HCC or metastases 5. Must be receiving or will plan to receive SBRT for Liver HCC or metastases Exclusion Criteria: 1. Allergy to iodine contrast 2. CT with contrast not offered as a Standard of Care 3. Pregnant women
References
Publications (0)
Data not yet available
No reference posted for this study.