Clinical trial · Interventional
Impact of Prehabilitation in Oncology Via Exercise- Bone Marrow Transplant
The Effects of a Prehabilitation Exercise Program in Adults Receiving a Hematopoietic Stem Cell Transplant
NCT03886909CI-TRIAL-00067898IMPROVE-BMTcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether patients are able to participate in a prehabilitation program (prior to the beginning of treatment) which includes: (1) a home-based exercise program or (2) just a prehabilitation education session.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hematologic Diseases | — | UNRESOLVED | — |
| Hematopoietic Stem Cell Transplant | — | UNRESOLVED | — |
| Physical Activity | — | UNRESOLVED | — |
| Prehabilitation | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise | Behavioral | — | UNRESOLVED |
| Prehabilitation Education | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Home-Based Prehabilitation
- description
- Will be offered an individual one-on-one appointment for an exercise introduction session with an exercise and cancer specialist and periodical phone calls to support and adapt the exercise program. The exercises should be done home-based for 5 times a week until the time of transplant.
- interventionNames
- Behavioral: Exercise
- type
- ACTIVE_COMPARATOR
- label
- Prehabilitation Education
- description
- Will be offered a prehabilitation and stem cell education class at the Penn State Hershey Cancer Institute.
- interventionNames
- Behavioral: Prehabilitation Education
Primary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Hematological cancer (e.g. Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, Multiple Myeloma, Non-Hodgkin Lymphoma, etc.) * Hematological cancer in remission * Females and males ≥18 years of age * Fluent in written and spoken English * Must be able to provide and understand informed consent * Must have an ECOG score of ≤ 2 * Scheduled for an inpatient autologous or allogeneic stem cell transplant at Penn State Cancer Institute * ≥ 2 weeks until scheduled transplant * Primary attending physician approval Exclusion Criteria: * Hematological cancer not in remission * Evidence in the medical record of an absolute contraindication (e.g. Heart insufficiency \> NYHA III or uncertain arrhythmia; uncontrolled hypertension; reduced standing or walking ability) for exercise * Any other comorbidities or musculoskeletal complications that preclude participation in the exercise programs as deemed by the exercise interventionist * Uncontrolled hypertension * Receiving non-transplant related chemotherapy and/or radiotherapy * Not fluent in written and spoken English * Active infections, hemorrhages, and cytopenias that could place transplant patients at risk for further adverse events, deemed by the exercise interventionist, physician and/or nurse
References
Publications (1)
- DERIVEDPotiaumpai M, Schmitz KH, Mineishi S, Naik S, Wirk B, Rakszawski K, Ehmann WC, Claxton D, Nickolich M, Zemel BS, Zheng H. IMPROVE-BMT: a protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients. BMJ Open. 2023 Jan 18;13(1):e066841. doi: 10.1136/bmjopen-2022-066841. PMID 36657760