Clinical trial · Observational
Complication and Lung Function Impairment Prediction Using Perfusion and CT Air Trapping
Complication and Lung Function Impairment Prediction Using Perfusion and CT Air Trapping (CLIPPCAIR): Protocol for the Development and Validation of a Novel Algorithm for Post-resection Lung Function
NCT03885765CI-TRIAL-00091237CLIPPCAIRcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for predicting post-operative forced expiratory volume in 1 second (FEV1) values for lung resection candidates; this new model will be based on data derived from a thoracic CT scan with injection of contrast media.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lung resection | Procedure | — | UNRESOLVED |
| Predictive data | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Test group
- description
- The first 60 patients recruited.
- interventionNames
- Diagnostic Test: Predictive data
- Procedure: Lung resection
- label
- Validation group
- description
- The last 100 patients recruited.
- interventionNames
- Diagnostic Test: Predictive data
- Procedure: Lung resection
Primary outcomes (2)
- measure
- Forced expiratory volume in 1 second (FEV1) from spirometry
- timeFrame
- 6 months
- measure
- Correlation between predicted and real values for post-surgical FEV1
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient diagnosed with non-small cell lung cancer * Indication for pulmonary excision surgery * Patient requiring a more recent pre-surgical computed tomography scan (CT scan) * The patient has been correctly informed about the study and has signed the consent form * The patient is affiliated with or a beneficiary of the French single-payer social security programme (national health insurance) Exclusion Criteria: * Patient in an exclusion period determined by another protocol * Participation in another study that may affect the results of the present study (anti-cancer treatment studies are allowed) * Patient under legal or judicial protection * Contraindication to surgery or iodine injection * Pregnant or lactating women
References
Publications (1)
- BACKGROUNDSuehs CM, Solovei L, Hireche K, Vachier I, Mariano Goulart D, Gamon L, Charriot J, Serre I, Molinari N, Bourdin A, Bommart S. Complication and lung function impairment prediction using perfusion and computed tomography air trapping (CLIPPCAIR): protocol for the development and validation of a novel multivariable model for the prediction of post-resection lung function. Ann Transl Med. 2021 Jul;9(13):1092. doi: 10.21037/atm-21-214. PMID 34423004