Clinical trial · Observational
Radiographic Validation of the Inferior Mesenteric Artery Tie Level in Rectal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The inferior mesenteric artery is the feeding vessel for tumours in the rectum. When performing surgery for these tumours, the surgeon can cut the vessel close to the aorta or after the vessel bifurcates to the superior rectal artery and the left colic artery. A close division is termed a high tie (and the other, a low tie) and might entail a better lymph node extraction, possibly removing metastasis, but can also lead to nerve damage and e.g. bowel dysfunction. There is no clear evidence favouring either tie level, and large amounts of data are needed to establish superiority as any effects is likely to be small. One such method is to use national registries with prospectively collected data on e.g. level of tie and cancer relapse. However, it is not always easy to determine the level of tie while in the operating room and registries might also contain erroneous data. In order to determine the validity of such data, comparisons to objective measures are needed. This study is an attempt to correlate radiographic imaging to the suggested tie level, as indicated by the surgeon in the operative report and by the nationwide Swedish Colorectal Cancer Registry. If the registry variable tie level has a high correlation with imagining, researchers can more reliably use the registry to establish the benefits and drawbacks with high tie in rectal cancer surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Sensitivity of registered level of tie
- timeFrame
- 1 year postoperatively
- description
- Sensitivity of level of tie in the Swedish Colorectal Cancer Registry, using radiological determination with computerized tomography as reference.
- measure
- Specificity of registered level of tie
- timeFrame
- 1 year postoperatively
- description
- Specificity of level of tie in the Swedish Colorectal Cancer Registry, using radiological determination with computerized tomography as reference.
Secondary outcomes (3)
- measure
- Artery stump length in low tie surgery
- timeFrame
- 1 year postoperatively
- description
- Stump length of the ligated inferior mesenteric artery in low tie surgery.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Operated for primary rectal cancer * 1-year radiological follow-up is planned * Ability to leave informed consent Exclusion Criteria: * Contrast medium insensitivity * Diagnosis of renal failure * Age below 40 years * Thyroid disease for which radioactive iodine treatment might be considered
References
Publications (1)
- DERIVEDWikner F, Matthiessen P, Sorelius K, Legrell P, Rutegard M. Discrepancy between surgeon and radiological assessment of ligation level of the inferior mesenteric artery in patients operated for rectal cancer-impacting registry-based research and surgical practice. World J Surg Oncol. 2021 Apr 13;19(1):115. doi: 10.1186/s12957-021-02222-5. PMID 33849560