Clinical trial · Interventional
Effects of Anesthesia on Tumor Immunity and Insulin Resistance During Perioperative Period
Effects of Drug or Drink Intervention and Temperature Protectionon for Cervical Cancer Patients on Insulin Resistance and Tumor Immunity
NCT03872635CI-TRIAL-00037572completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate the effects of preoperative oral carbohydrate on postoperative insulin resistance and tumor immunity in cervical cancer patients with neoadjuvant chemotherapy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia | — | UNRESOLVED | — |
| Carbohydrate | — | UNRESOLVED | — |
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Tumor Immunity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| oral carbohydrate liquid | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- CHO Drinking Grope
- description
- receive 300mL of an oral carbohydrate liquid supplement 2 hour before surgery
- interventionNames
- Other: oral carbohydrate liquid
- type
- NO_INTERVENTION
- label
- Traditional fast Grope
- description
- fast on standard hospital protocol (8 hour fasting for solid and 4 hour fasting for clear liquid
Primary outcomes (1)
- measure
- insulin resistance
- timeFrame
- in 24 hrs
- description
- The patient's insulin resistance was determined by fasting plasma glucose(FPG),fastingainsulin(FINS), andHOMA-IR=FPG（mmol/L）×FINS（mIU/L）/22.5
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. The patients aged from 18 to 60 years old were ASA level I to II, and the informed consent was signed by the patients, which was approved by the ethics committee of the hospital. 2. Cervical squamous cell carcinoma was confirmed by cervical biopsy before pathologic surgery. CT showed no distant metastasis. All patients underwent total hysterectomy, bilateral adnexectomy and pelvic lymph node dissection. 3. Fasting blood glucose was normal without diabetes, impaired glucose tolerance or other metabolic diseases. 4. no gastric emptying dysfunction. Exclusion Criteria: 1. Dabetes 2. Patients with obstruction of gastric emptying, such as pyloric obstruction, gastroesophageal reflux, nausea and vomiting, etc 3. Obese (BMI \>32) or severely malnourished (BMI\<18.5) 4. Distant metastasis, multiple primary cancers and recurrent tumors 5. Patients with functional disorders of respiratory system, circulatory system, immune system, nervous system, urinary system and other organs 6. Received blood transfusion and nutritional support within 2 weeks before surgery 7. The supplement contains the sugar solution, the blood transfusion, the application glucocorticoid, the sympathetic blood vessel activity medicine in the operation.
References
Publications (1)
- DERIVEDZhang F, Yao M, Lin Z, Chen Y, Jiang H, Zeng M, Chen W. The Effects of Preoperative Oral Carbohydrate on Frequency of T and NK Cells in Patients with Cervical Cancer Treated Using Neoadjuvant Chemotherapy and Surgery: A Prospective Cohort Study. Biomed Res Int. 2020 Mar 16;2020:2101480. doi: 10.1155/2020/2101480. eCollection 2020. PMID 32309426