Clinical trial · Observational
Radiomics Multifactorial Biomarker for Pulmonary Nodules
Radiomics and Clinical Variables Can Differentiate Malignant Nodules and Detect Invasive Adenocarcinoma in Pulmonary Nodules: a Multi-center Study
NCT03872362CI-TRIAL-00037589RMBPNcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators aim to investigate the utility of radiomics to differentiate malignant nodules from benign nodules and invasive adenocarcinoma from non-invasive adenocarcinoma.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Non-Small-Cell Lung | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Lung Diseases | — | UNRESOLVED | — |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
| Pathology | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| radiomics | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Training dataset
- description
- No interventions
- interventionNames
- Diagnostic Test: radiomics
- label
- External validation1
- description
- No interventions
- interventionNames
- Diagnostic Test: radiomics
- label
- External validation2
- description
- No interventions
- interventionNames
- Diagnostic Test: radiomics
Primary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * intraoperative frozen section diagnosis and final pathology diagnosis are available * preoperative standard non-enhanced CT is available * Pathologically confirmed Exclusion Criteria: * with a previous history of radiation therapy, chemotherapy or biopsy * the time interval between the CT examination and surgery was more than two weeks
References
Publications (1)
- DERIVEDWu G, Woodruff HC, Shen J, Refaee T, Sanduleanu S, Ibrahim A, Leijenaar RTH, Wang R, Xiong J, Bian J, Wu J, Lambin P. Diagnosis of Invasive Lung Adenocarcinoma Based on Chest CT Radiomic Features of Part-Solid Pulmonary Nodules: A Multicenter Study. Radiology. 2020 Nov;297(2):451-458. doi: 10.1148/radiol.2020192431. Epub 2020 Aug 25. PMID 32840472