Clinical trial · Interventional
Prehabilitation of Frail Surgical Cancer Patients Using Remote Ischemic Preconditioning
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This project will examine the efficacy of a simple, cost-effective, non-invasive intervention, called remote ischemic preconditioning (RIPC), to reduce frailty in pre-surgical, frail, elderly patients with colon cancer. The investigators hypothesize that RIPC will reduce frailty in the pre-surgical period (as assessed by distance walked during the 6-minute walk test), improve functional capacity 4-weeks postoperatively, and reduce intraoperative blood pressure variability. If successful, future studies will examine the efficacy of RIPC to improve surgical outcomes in frail cancer patients.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Fragility | — | UNRESOLVED | — |
| Prehabilitation | — | UNRESOLVED | — |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Remote Ischemic Preconditioning | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Standard of Care
- description
- Study participants will receive standard of care.
- type
- EXPERIMENTAL
- label
- Remote Ischemic Preconditioning
- description
- Study participants will perform remote ischemic preconditioning daily, at home, from study enrollment to their date of surgery.
- interventionNames
- Procedure: Remote Ischemic Preconditioning
Primary outcomes (1)
- measure
- 6 Minute Walk Test Distance (Pre Surgery)
- timeFrame
- Pre-Surgery
- description
- The investigators will compare the distance study participants can walk in 6 minutes in the pre-surgical period as a measure of frailty.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 55 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Be between the ages of 55-85 * Have a positive diagnosis of colon cancer or suspected colon cancer based on pathology report * Be scheduled for curative resection of non-metastatic colon cancer * Have a 6-Minute Walk Test distance ≤80% of predicted value based on age and sex. Exclusion Criteria: * Condition which prevents walking * Any condition in which compression of the arm or transient ischemia is contraindicated (e.g. wounds in the arm) * Neurodegenerative disorder * Unstable angina in previous month * Myocardial infarction during previous month.
References
Publications (0)
Data not yet available