Simultaneous Portal and Hepatic Vein Versus Portal Vein Embolizations for Hypertrophy of the Future Liver Remnant

Inclusion Criteria:

* Liver metastases from colo-rectal origin considered as resectable (as validated by a multidisciplinary committee with at least one senior hepatic surgeon) provided sufficient FRL volume
* Percentage of FRL volume \< 30%
* Age ≥ 18 years
* General health status World Health Organisation 0,1
* Estimated life expectancy \> 3 months
* Patients whose biological parameters are :

  * Platelets ≥100,000/mm3,
  * Polynuclear neutrophils ≥ 1000/mm3,
  * Hemoglobin≥ 9g/dL (even transfused patients can be included)
  * Creatininemia \< 1.5 times the normal value
  * Creatinine clearance \> 30 milliliters (mL)/min
  * Bilirubinemia ≤ 1,5 times the normal value
  * liver transaminases ≤ 5 times the normal value
  * prothrombin rate \> 70%
* Reference liver CT-Scan or MRI done during the 30 days preceding PVE or LVD.
* Written informed consent
* National health insurance cover

Exclusion criteria

* Patient with cirrhosis
* Presence of clinical ascites
* Ongoing participation or participation within the 21 days prior to inclusion in the study in another therapeutic trial with an experimental drug
* Serious non-stabilized disease, active uncontrolled infection or other serious underlying disorder likely to prevent the patient from receiving the treatment
* Pregnancy (betaHCG positive), breast-feeding or the absence of effective contraception for women of child-bearing age
* Contraindication for the MRI : Pacemaker or neurosensorial stimulator or implantable defibrillator, cochlear implant, ferromagnetic foreign body similar to the nervous structure.
* Allergy or contra-indication to iodine contrast agents (thyrotoxicosis, allergy to the active substance or excipients)
* Treatment with anticoagulants (heparin or AVK) that cannot be interrupted for 48 hours
* Treatment with anti-platelets that cannot be interrupted for 5 days for aspirin or Plavix
* Legal incapacity (persons in custody or under guardianship)
* Deprived of liberty Subject (by judicial or administrative decision)
* Impossibility to sign the informed consent document or to adhere to the medical follow-up of the trial for geographical, social or psychological reasons