Clinical trial · Observational
Oesophagectomy and Chest Wall and Respiratory Function
Changes in Respiratory Function and Chest Wall Movement Following Oesophagectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Study closed before the planned recruitment target was reached because the study period ended before full recruitment could be completed. Recruitment ceased at study closure and data collection was completed for enrolled participants.
Summary
Brief summary (as posted)
Open surgery for esophageal cancer commonly involves large incisions in the chest, associated with a high rate of pulmonary complications (30-50%). Minimally invasive approach through keyhole surgery has been shown to reduce pulmonary infections by 20%. Enhanced recovery programmes are evidence-based protocols, developed to achieve early recovery after surgery with early mobilisation and chest physiotherapy and have been shown to reduce pulmonary complication rates as well. The investigators intend to objectively measure chest wall movement using 3D motion capture system as well as a wearable measurement system to monitor chest wall movement.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Esophagectomy | — | UNRESOLVED | — |
| Respiratory Function Loss | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 3D motion capture system | Other | — | UNRESOLVED |
| Incentive spirometry | Other | — | UNRESOLVED |
| Questionnaires | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Control group
- description
- Fourty control participants who have not received upper gastrointestinal surgery.
- interventionNames
- Other: 3D motion capture system
- Other: Incentive spirometry
- Other: Questionnaires
- label
- Open surgery
- description
- Sixty patients who have undergone open removal of oesophagus more than one year ago.
- interventionNames
- Other: 3D motion capture system
- Other: Incentive spirometry
- Other: Questionnaires
Primary outcomes (2)
- measure
- Chest wall movement
- timeFrame
- Each participant will undergone one assessment during the study. The whole session, all procedures included, will last approximately 60 minutes.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Exposure group: 1. Patients treated more than a year ago with oesophagectomy for oesophageal cancer, by an open approach. 2. Patients able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study. * Control group: 1. Healthy volunteers with no underlying respiratory disease and no history of upper gastrointestinal surgery. 2. Individuals able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study. Exclusion Criteria: * Any participant who lacks capacity or is unable to provide informed consent. * Any participant younger than 18 or older than 90 years of age. * Any patient with evidence of cancer recurrence or on-going postoperative complication at more than one year following surgery for oesophageal cancer. * Any pregnant participant. * unable to or excluded from performing spirometry or respiratory muscle strength testing (non-invasive testing)
References
Publications (8)
- BACKGROUNDShirinzadeh A, Talebi Y. Pulmonary Complications due to Esophagectomy. J Cardiovasc Thorac Res. 2011;3(3):93-6. doi: 10.5681/jcvtr.2011.020. Epub 2011 Aug 20. PMID 24250962
- BACKGROUNDNagawa H, Kobori O, Muto T. Prediction of pulmonary complications after transthoracic oesophagectomy. Br J Surg. 1994 Jun;81(6):860-2. doi: 10.1002/bjs.1800810622. PMID 8044603
- BACKGROUNDBiere SS, van Berge Henegouwen MI, Maas KW, Bonavina L, Rosman C, Garcia JR, Gisbertz SS, Klinkenbijl JH, Hollmann MW, de Lange ES, Bonjer HJ, van der Peet DL, Cuesta MA. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet. 2012 May 19;379(9829):1887-92. doi: 10.1016/S0140-6736(12)60516-9. Epub 2012 May 1. PMID 22552194
- BACKGROUNDKubo N, Ohira M, Yamashita Y, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Shibutani M, Yamazoe S, Kimura K, Nagahara H, Amano R, Ohtani H, Yashiro M, Maeda K, Hirakawa K. The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer. Anticancer Res. 2014 May;34(5):2399-404. PMID 24778050
- BACKGROUNDSchmidt HM, El Lakis MA, Markar SR, Hubka M, Low DE. Accelerated Recovery Within Standardized Recovery Pathways After Esophagectomy: A Prospective Cohort Study Assessing the Effects of Early Discharge on Outcomes, Readmissions, Patient Satisfaction, and Costs. Ann Thorac Surg. 2016 Sep;102(3):931-939. doi: 10.1016/j.athoracsur.2016.04.005. Epub 2016 Jun 7. PMID 27283109
- BACKGROUNDLi C, Ferri LE, Mulder DS, Ncuti A, Neville A, Lee L, Kaneva P, Watson D, Vassiliou M, Carli F, Feldman LS. An enhanced recovery pathway decreases duration of stay after esophagectomy. Surgery. 2012 Oct;152(4):606-14; discussion 614-6. doi: 10.1016/j.surg.2012.07.021. Epub 2012 Sep 1. PMID 22943844