Clinical trial · Observational
8-Hydroxy-2-Deoxyguanosine ,Total Antioxidant Capacity in Oral Premalignant and Malignant Lesions
Detection of Salivary 8-Hydroxy-2-Deoxyguanosine and Total Antioxidant Capacity in Patients With Oral Premalignant and Malignant Lesions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Objectives: Investigating the level of salivary 8-hydroxy-2-deoxyguanosine (8-OHdG) and total antioxidant capacity (TAC) in oral premalignant and malignant lesions in order to determine their diagnostic value for the malignant patients. Design: 120 subjects diagnosed with oral leukoplakia, oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) along with healthy control subjects were included. Salivary samples from all participants were collected. 8-OHdG was measured by ELISA technique and the TAC level was assessed by a photometric test system.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Premalignant Lesion | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (4)
- label
- Group A
- description
- 30 patients diagnosed with oral leukoplakia
- label
- Group B
- description
- 30 patients diagnosed with oral lichen planus
- label
- Group C
- description
- 30 patients having oral squamous cell carcinoma with the tongue being the most commonly affected site
- label
- Group D
- description
- 30 age and gender matched individuals having no oral mucosal lesions acting as a control group
Primary outcomes (2)
- measure
- Salivary 8-OHdG
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 63 Years
Show eligibility criteria text
Inclusion Criteria: All included individuals were not under any current medication, suffering from any systemic condition or having any other oral mucosal disorder. Exclusion Criteria: 1. Pregnant or lactating females 2. subjects having systemic disorder or taking medications; 3. subjects who suffer from any other mucosal lesions. 4. severe periodontal inflammation
References
Publications (0)
Data not yet available