Clinical trial · Interventional
Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound
NCT03829618CI-TRIAL-00054392terminatedPhase 3Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): COVID lack of cases/recruitment
Summary
Brief summary (as posted)
The purpose of this study is to assess if there is decrease in cough during flexible bronchoscopy and endobronchial ultrasound when different modes of lidocaine administration are used. The modes of administration being evaluated are topical, nebulized and atomized.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bronchiectasis Adult | — | UNRESOLVED | — |
| Bronchopulmonary Disease | — | UNRESOLVED | — |
| Cancer, Lung | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Chest--Diseases | — | UNRESOLVED | — |
| Infiltrates | — | UNRESOLVED | — |
| Mediastinal Lymphadenopathy | — | UNRESOLVED | — |
| Pneumonia | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nebuliser solution | Drug | — | UNRESOLVED |
| Nebuliser Suspension | Drug | — | UNRESOLVED |
| Topical lidocaine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Topical Lidocaine
- description
- 16 ml of 1% lidocaine sprayed in 4 ml aliquots to vocal cords, midtrachea, left main stem bronchus and right main stem bronchus.
- interventionNames
- Drug: Topical lidocaine
- type
- ACTIVE_COMPARATOR
- label
- Nebuliser Solution
- description
- 2% lidocaine dosed at 2mg/kg with max dose of 160mg nebulized via jet nebulizer in operating room over ten minutes.
- interventionNames
- Drug: Nebuliser solution
- type
- ACTIVE_COMPARATOR
- label
- Nebuliser Suspension
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of mediastinal and/or hilar lymphadenopathy requiring endobronchial ultrasound evaluation and transbronchial needle aspiration. * Diagnosis of pulmonary disease requiring flexible bronchoscopy * Greater than 18 years of age. Exclusion Criteria: * Any intervention beyond flexible bronchoscopy and endobronchial ultrasound * Inability to tolerate bronchoscopy. * Patients that receive paralytics. * Patients with neuromuscular diseases. * Inability to consent for procedures. * Allergies to lidocaine or any other drugs used in protocol. * Existing renal insufficiency or liver disease
References
Publications (5)
- BACKGROUNDMadan K, Biswal SK, Mittal S, Hadda V, Mohan A, Khilnani GC, Pandey RM, Guleria R. 1% Versus 2% Lignocaine for Airway Anesthesia in Flexible Bronchoscopy Without Lignocaine Nebulization (LIFE): A Randomized Controlled Trial. J Bronchology Interv Pulmonol. 2018 Apr;25(2):103-110. doi: 10.1097/LBR.0000000000000458. PMID 29346249
- BACKGROUNDStolz D, Chhajed PN, Leuppi J, Pflimlin E, Tamm M. Nebulized lidocaine for flexible bronchoscopy: a randomized, double-blind, placebo-controlled trial. Chest. 2005 Sep;128(3):1756-60. doi: 10.1378/chest.128.3.1756. PMID 16162784
- BACKGROUNDWahidi MM, Jain P, Jantz M, Lee P, Mackensen GB, Barbour SY, Lamb C, Silvestri GA. American College of Chest Physicians consensus statement on the use of topical anesthesia, analgesia, and sedation during flexible bronchoscopy in adult patients. Chest. 2011 Nov;140(5):1342-1350. doi: 10.1378/chest.10-3361. PMID 22045879
- BACKGROUNDDreher M, Cornelissen CG, Reddemann MA, Muller A, Hubel C, Muller T. Nebulized versus Standard Local Application of Lidocaine during Flexible Bronchoscopy: A Randomized Controlled Trial. Respiration. 2016;92(4):266-273. doi: 10.1159/000449135. Epub 2016 Sep 10. PMID 27614989
- RESULTAmini S, Peiman S, Khatuni M, Ghalamkari M, Rahimi B. The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial. J Bronchology Interv Pulmonol. 2017 Oct;24(4):263-267. doi: 10.1097/LBR.0000000000000385. PMID 28891835