Clinical trial · Observational
Oocyte Freezing for Fertility Preservation in Benign Ovarian Tumors
Systematic Proposal of Fertility Preservation by Oocyte Freezing in Case of Benign Ovarian Tumors With High Risk of Recurrence
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Benign ovarian cysts are frequent during women's life. They are diagnosed with pelvic pain or fortuitously during an ultra-sonographic exam. In case of persistence,a surgery will be necessary to identify the nature of the cyst and assess its benignity. In some case, cysts are recurrent and multiple surgeries are needed leading to a significant risk of ovarian damage by follicular depletion. Oocyte cryopreservation is no longer considered as an experimental technique of Fertility Preservation since 2013 as it has been recognized to be efficient and safe. According to reproductive medicine scientific committees and the French ethic law, fertility preservation has to be proposed in every situation of infertility risk. To date, there is no cohort study dedicated to fertility preservation by oocyte freezing in this specific subgroup of patients. The purpose of the study is to prospectively evaluate the oocyte number and quality after controlled ovarian hyperstimulation in patients with recurrent ovarian cysts.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dermoid Cyst | Dermoid Cyst | ONTOLOGY_EXACT | 0.98 |
| Endometriosis | — | UNRESOLVED | — |
| Mucinous Cyst | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Number of mature oocytes eligible for cryopreservation
- timeFrame
- After 15 days of controlled ovarian hyperstimulation (COH)
Secondary outcomes (3)
- measure
- Percentage of immature or morphologically abnormal oocytes
- timeFrame
- Real-time, the day of egg retrieval
- measure
- Number of mature follicles (≥15 mm) and intermediary (10-14 mm) during ovarian stimulation
- timeFrame
- The day of HCG triggering at the end of ovarian stimulation
- measure
- Questionnaire on tolerance and complications
- timeFrame
- One week after the egg retrieval
- description
- A systematic telephone interview will be carried out 48 to 72 hours after the oocyte puncture to judge the tolerance of the procedure.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * women with benign ovarian tumor with high risk of recurrence, i-e, endometrioma, dermoid cysts or mucinous cysts. * women with previous surgery and/or high risk of ovarian damage: bilateral cysts, cyst diameter higher than 5 cms * Having a social insurance * Able to give an informed consent Exclusion Criteria: * Borderline tumors * Undetectable AMH levels * Personal history of thrombo-embolic events * pregnancy
References
Publications (0)
Data not yet available