VAccination in Early and ADvanced Prostate caNCEr

Inclusion Criteria:

For all participants:

* Histologically confirmed adenocarcinoma of the prostate cancer
* Any antineoplastic therapy must have been completed a minimum of 28 days prior to enrolment
* Systemic antimicrobial therapy must have been completed a minimum of 7 days prior to enrolment
* An archival specimen of tumour tissue should be available
* Baseline laboratory parameters must meet the following criteria:

Haemoglobin ≥ 80 g/L, White cell count ≥ 2.0 x10\^9/L, Neutrophils ≥ 1.5 x10\^9/L, Lymphocytes ≥ 0.5 x10\^9/L, Platelets ≥ 100 x10\^9/L, Creatinine Clearance ≥ 40 ml/min by Cockcroft Gault formulation, Total Bilirubin ≤ 1.5 ULN, Alanine Aminotransferase ≤ 1.5 ULN, Amylase ≤ 1.5 ULN

For surgical cohort:

* Clinically localised or locally advanced disease deemed operable by the treating consultant urological surgeon i.e.: Gleason score ≤ 7, local tumour stage ≤T3c and deemed operable, no evidence of metastases (Nx/N0 and Mx/M0), no evidence of high grade Gleason 5 disease, PSA ≤ 20 ng/ml
* Scheduled for and considered fit for radical prostatectomy

For advanced metastatic cohort:

* Evidence of at least one distant metastasis based on MRI, CT, PET or bone scintigraphy
* Established on and suitable to continue with androgen deprivation therapy (ADT) using any luteinizing hormone releasing hormone (LHRH) agonist
* On treatment with anti-androgen therapy using either abiraterone (Zytiga®) or enzalutamide (Xtandi®) and demonstrating evidence of disease progression at the time of enrolment
* Suitable to continue therapy with either abiraterone or enzalutamide at the time of enrolment at discretion of their managing clinician
* Patients who have received chemotherapy following progression on androgen-targeting therapies are eligible
* Satisfactory functional status defined as ECOG Performance Status ≤ 1

Exclusion Criteria:

For all participants:

* Any prior diagnosis or clinical suspicion of autoimmune disease
* History of allergic disease or reaction likely to be exacerbated by any component of the vaccine, e.g. egg products
* Other prior malignancy with an estimated ≥ 30% chance of relapse within 2 years
* Participation in another research study involving an investigational product or investigational surgical procedure in the 30 days preceding enrolment, or planned use during the study period
* Any prior exposure to checkpoint inhibitor drugs including anti-PD-1, anti-PD-L1, or anti-CTLA-4 monoclonal antibodies or any prior treatment with investigational vaccines
* Administration of immunoglobulins and/or any blood products within the one month preceding the planned administration of the study drugs
* Seropositive for hepatitis B surface antigen (HBsAg)
* Seropositive for hepatitis C virus (antibodies to HCV)
* Any confirmed or suspected immunocompromised state
* Any history of hereditary angioedema, acquired angioedema, or idiopathic angioedema
* History of anaphylaxis in relation to vaccination or any clinically significant allergic disease likely to be exacerbated by any component of the vaccine or checkpoint inhibitor preparations

For advanced metastatic cohort:

* The treating oncologist estimates a subject's life expectancy to be ≤ 6 months
* Any active, previously treated, or suspected intracranial or leptomeningeal metastases