Nab-paclitaxel Combined With S-1 as Induction Therapy for Locally Advanced Pancreatic Cancer

Inclusion Criteria:

* patient compliance is good, the research process of this study can be understood, and written informed consent is signed;
* Age ≥ 18 years old, ≤ 75 years old;
* Histologically or cytologically confirmed pancreatic adenocarcinoma；
* no prior treatment;
* Based on imaging findings, MDT decided patients intoborderline resectable (group A) or unresectable (group B) (according to the resectability assessment criteria in the 2018 Pancreatic Cancer Comprehensive Care Guidelines);
* ECOG\<2;
* Bone marrow function: hemoglobin (HGB) ≥ 90g / L; absolute neutrophil count (ANC) ≥ 1.5 × 109 / L; platelets (PLT) ≥ 100 × 109 / L;
* Liver function: ALT, AST ≤ 2.5 × upper limit of normal (ULN), if there is liver metastasis, ALT, AST ≤ 5 × ULN; serum total bilirubin \< 1.5 × ULN;
* Renal function: serum creatinine is within normal range;
* Patients without biliary obstruction, patients requiring biliary stent implantation must be completed at least 7 days prior to enrollment;
* Non-pregnant and lactating women, women of reproductive age/male should take effective contraceptive measures during the study period and within 6 months after the end of the study treatment;
* No contraindication to the use of S-1and albumin-bound paclitaxel.

Exclusion Criteria:

* Patients who have had other malignant tumors within 5 years (except for cured cervical cancer in situ or non-melanoma skin cancer);
* Interstitial pneumonia or pulmonary fibrosis;
* Severe pleural effusion or ascites;
* Watery diarrhea;
* There are serious concomitant diseases: such as HIV-positive,chronic HBV/HCV in active period, people who have diabetes and poorly controlled by hypoglycemic drugs, clinically severe (ie, active) heart disease, uncontrolled epilepsy, central nervous system disease or mental disorder;
* Current or previous patients with grade II peripheral neuropathy;
* Abnormal digestive tract or metabolic function, which may affect the s-1 absorber;
* Participated in other clinical researchers within 4 weeks prior to enrollment;
* Patients who have undergone organ transplantation;
* Patients considered by the investigator to be unfit for this trial.