Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer

Inclusion Criteria:

* Ability to understand and the willingness to sign a written informed consent document
* Must be listed or recommended to be listed for orthotopic liver transplantation at the participating institution
* Have a Child-Pugh (CP) score \>= B8
* Eastern Clinical Oncology Group (ECOG) performance status =\< 2, or Karnofsky performance scale \> 60
* Must have a life expectancy \> 12 weeks
* Safe radiation treatment planning parameters that adhere to all organs at risk constraints per section 5.1 of the protocol. If normal organs at risk constraints (including at least 700cc of uninvolved liver) are unable to be met at the lowest dose modification (30 Gy in 5 fractions), the patient is deemed ineligible for SBRT and deemed a screen failure
* Except for prior radiotherapy or radioembolization, other prior therapies to previously treated lesions, are permitted
* People of childbearing potential must have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of SBRT. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required
* Participants of childbearing potential are those who have not been surgically sterilized or have not been free from menses for \> 1 year without an alternative medical cause

  * Note: Abstinence is acceptable if this is the preferred contraception for the participant
* No other prior invasive malignancy is allowed except for the following: adequately treated basal (or squamous cell) skin cancer, in situ breast or cervical cancer. Stage I or II invasive cancer treated with a curative intent without evidence of disease recurrence for at least five years

Exclusion Criteria:

* Participants have any one of the following liver tumor characteristics:

  * Have \> 5 liver tumors, or
  * Maximal diameter \> 5 cm
* Complete obstruction of portal venous flow to the segment of liver that includes the target lesion
* Prior radiotherapy to the upper abdomen or radioembolization of the liver, or prior thermal ablation to the target lesion
* For fiducial marker placement:

  * Have a gold allergy
  * Any coagulopathy preventing safe fiducial placement
* Contraindication to both contrast enhanced magnetic resonance imaging (MRI) and contrast enhanced computed tomography (CT) (i.e. unable to undergo follow-up imaging or SBRT treatment planning)
* Participation in another concurrent treatment protocol
* Participant is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial, starting with the screening visit through 120 days after the last dose of trial treatment
* Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring adverse events (AEs) or compromise the ability of the patient to give written informed consent