The Efficacy and Drug Resistance Molecular Biology of Apatinib Combined With EGFR-TK1 Treated for Advanced Slow-progressed Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

1. Informed consent should be obtained before treatment. Patients with good compliance.
2. Histologically or cytologically confirmed IIIB/IV NSCLC.
3. Progress in the treatment of EGFR TKI.
4. Aged from 18 to 75 years (18 and 75 years are included); Gender Not Required.
5. ECOG PS 0-1.
6. Life expectancy ≥ 3 months.
7. At least one measurable lesion (meet the requirements of the standard Response Evaluation Criteria In Solid Tumors (RESCIST) version 1.1). If the lesions that have received local treatment (radiation, radiofrequency, intervention, etc.) are the only lesions, it is required to have clear imaging progress.

Exclusion Criteria:

1. Uncontrolled hypertension (systolic ≥140mmHg and/or diastolic ≥90mmHg after medication treatment); Poor control of blood sugar.
2. Acute phase of cerebral infarction, or recovery period \<2 months.
3. A variety of factors that affect the absorption of oral medications (such as inability to swallow, nausea and vomiting, chronic diarrhea, intestinal obstruction, etc.)
4. Patients with a risk of gastrointestinal bleeding may not be enrolled, including the following: (1) active digestive ulcer lesions, and fecal occult blood (++); (2) a history of melena and hematemesis within 2 months. Simple fecal occult blood (+) is not an exclusion criterion.
5. Coagulation abnormality (INR\>1.5×ULN, APTT\>1.5×ULN), with bleeding tendency.
6. Urine protein ≥ ++ or confirmed 24-hour urine protein quantitation \> 1.0 g.
7. Pregnant or lactating women.
8. Severe liver and kidney dysfunction (grade 4) .
9. Allergic to any ingredient of apatinib mesylate.
10. A history of abuse of psychotropic substances and are unable to quit smoking or mental disorders.
11. According to the investigator's judgment, people with concomitant diseases that seriously endanger the safety of the patient or affect the patient's completion of the study.
12. Surgery, major trauma or fracture, within 4 weeks before the treatment or unhealed wound before treatment.
13. Severe heart disease, such as grade III or above (NYHA standard) congestive heart failure, grade III or above (CCS standard) angina, a history of myocardial infarction within 6 months before the treatment, or medication treated arrhythmia.
14. Brain metastasis and meningeal metastasis.