Clinical trial · Interventional
Bipolar RFA Using Twin ICW Electrodes vs. Switching Monopolar RFA for Recurrent HCC
Radiofrequency Ablation Using Internally Cooled Wet Electrodes in Bipolar Mode for the Treatment of Recurrent Hepatocellular Carcinoma After Locoregional Treatment: A Randomized Prospective Comparative Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study was conducted to provide preliminary data for the main trial to compare efficacy between bipolar radiofrequency ablation (RFA) using twin internally cooled-wet electrodes and switching monopolar RFA using separable clustered electrodes in the treatment of recurrent hepatocellular carcinoma (HCC) after locoregional treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bipolar RFA | Device | — | UNRESOLVED |
| Separable clustered electrodes | Device | — | UNRESOLVED |
| SM-RFA | Device | — | UNRESOLVED |
| Twin internally cooled-wet electrodes | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- TICW-RFA
- description
- Bipolar RFA using twin internally cooled-wet electrodes
- interventionNames
- Device: Bipolar RFA
- Device: Twin internally cooled-wet electrodes
- type
- ACTIVE_COMPARATOR
- label
- SC-RFA
- description
- Switching monopolar RFA using separable clustered electrodes
- interventionNames
- Device: SM-RFA
- Device: Separable clustered electrodes
Primary outcomes (1)
- measure
- Minimum diameter of ablation zone per unit time
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * radiologic or pathologic diagnosis of HCC recurrence after locoregional treatment * HCC nodules measuring 1 cm or larger and smaller than 5 cm Exclusion Criteria: * more than three HCC nodules * tumors with major vascular invasion or abutment to the central portal or hepatic vein with a diameter \> 5mm * extrahepatic metastasis * Child-Pugh class C * severe coagulopathy (platelet cell count of less than 50,000 cells/mm3 or prothrombin time international normalized ratio (PT-INR) prolongation of more than 50 %)
References
Publications (1)
- DERIVEDChoi JW, Lee JM, Lee DH, Yoon JH, Kim YJ, Lee JH, Yu SJ, Cho EJ. Radiofrequency ablation using internally cooled wet electrodes in bipolar mode for the treatment of recurrent hepatocellular carcinoma after locoregional treatment: A randomized prospective comparative study. PLoS One. 2020 Sep 28;15(9):e0239733. doi: 10.1371/journal.pone.0239733. eCollection 2020. PMID 32986758