Clinical trial · Interventional
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
Molecular Typing and Precise Prevention and Treatment of Peutz-Jeghers Syndrome
NCT03806075CI-TRIAL-00036571unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11, APC,PMS1,et al. Furtherly, the investigators analyze the association of STK11 with gut microbiota.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Peutz-Jeghers Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 16s rRNA gene sequencing | Behavioral | — | UNRESOLVED |
| Second generation sequencing | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Peutz-Jeghers patients
- description
- All Peutz-Jeghers patients meet the clinical criteria
- interventionNames
- Behavioral: Second generation sequencing
- Behavioral: 16s rRNA gene sequencing
- type
- PLACEBO_COMPARATOR
- label
- Health persons
- description
- Those without Peutz-Jeghers syndrome
- interventionNames
- Behavioral: 16s rRNA gene sequencing
Primary outcomes (1)
- measure
- Mutation of gene associated with Peutz-Jeghers syndrome
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 5 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Subject with ages from 18-70 years old. 2. Subject diagnosed with Peutz-Jeughers syndrome. 3. Subject without hypertension, diabetes and other gastrointestinal diseases. 4. The consent form has been signed. Exclusion Criteria: 1. Subject is younger than 18 years or older than 70 years. 2. Subject with hypertension,diabetes and other gastrointestinal diseases. 3. Subject taken or adminstered medicine associated with digestive function during latest 1 month. 4. Pregnant women.
References
Publications (0)
Data not yet available
No reference posted for this study.