Clinical trial · Interventional
Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
Effect of Compliance Guided an Optimal Positive End-Expiratory Pressure on Arterial Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
NCT03804398CI-TRIAL-00036522completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To observe the effect of compliance guided an optimal Positive End-Expiratory Pressure（PEEP）on arterial oxygenation and intrapulmonary shunt during one-lung ventilation(OLV)，and discuss the lung protective effect of optimal PEEP during one-lung ventilation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| compliance guided an optimal Positive End-Expiratory Pressure | Device | — | UNRESOLVED |
| PEEP level of 5 cmH2O | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- optimal PEEP group
- description
- The study group titrate PEEP from 4cmH2O,increased in 2cmH2O steps and hold at each step for 1min,and the static pulmonary compliance(Cst) would be record.Optimal PEEP was determined until the maximal static pulmonary compliance was obtained
- interventionNames
- Device: compliance guided an optimal Positive End-Expiratory Pressure
- type
- ACTIVE_COMPARATOR
- label
- PEEP level of 5 cmH2O group
- description
- In the control group at PEEP level of 5 cmH2O was established and maintained during the study period
- interventionNames
- Device: PEEP level of 5 cmH2O
Primary outcomes (1)
- measure
- arterial oxygenation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 18 yr to 65 yr * Body mass index(BMI)18-28kg/m2 * American Society of Anesthesiologists Physical Status Classifications I to II * Normal cardiac and pulmonary function * Diagnosed with uncomplicated lung cancer and was to receive video-assist thoracoscopic lobectomy under general anesthesia. Exclusion Criteria: * Forced expiratory volume at one second/forced vital capacity \<70% * Asthma * Chronic obstructive pulmonary disease * Acute lung infection * Past history of thoracic surgery * Cardiac,hepatic,renal and endocrine diseases * Preoperative glucocorticoid medication * Preoperative chemotherapy * Peripheral oxygen saturation（SpO2） kept below 90% for more than 10 minutes during operation * Blood transfusion during operation * Duration of one-lung ventilation less than an hour * Occurrence of severe complications like allergic shock
References
Publications (0)
Data not yet available
No reference posted for this study.