Clinical trial · Interventional
Routine Lymphadenectomy for Intrahepatic Cholangiocarcinoma
Impact of Routine Lymphadenectomy on Prognosis of Patients Undergoing Curative Resection for Intrahepatic Cholangiocarcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The role of routine lymphadenectomy (LND) in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) remains controversial. The investigators' multi-institutional retrospective study have showed an increasing adoption of LND among patients undergoing curative resection for ICC during the last decade. The current prospective and randomized study based on a multi-institutional collaboration would investigate whether routine LND would benefit patients in short- and long-term survival remains.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Intrahepatic Cholangiocarcinoma | Intrahepatic Cholangiocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| lymphadenectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- lymphadenectomy
- description
- This group of patients would undergo routine hepatoduodenal lymphadenectomy combined with ICC resection
- interventionNames
- Procedure: lymphadenectomy
- type
- NO_INTERVENTION
- label
- No lymphadenectomy
- description
- This group of patients would not undergo hepatoduodenal lymphadenectomy when preoperative imaging and intraoperative exploration found no lymph node enlargement.
Primary outcomes (2)
- measure
- 1-year recurrence rate
- timeFrame
- 1 year after surgery (up to 1 year)
- description
- compare the 1-year recurrence rate of patients undergoing lymphadenectomy and those not undergoing lymphadenectomy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed with intrahepatic cholangiocarcinoma by imaging or biopsy * The tumor is limited in the liver with no distant metastasis, and the primary disease is resectable * Preoperative imaging (e.g. CT, MRI, PET-CT, etc.) and intraoperative exploration found no nodal swelling or enlargement Exclusion Criteria: * The primary disease is unresectable with or without distant metastasis * The liver function or general condition of patients does not permit surgery * Preoperative imaging (e.g. CT, MRI, PET-CT, etc.) and intraoperative exploration found obvious nodal swelling or enlargement, which indicates lymphadenectomy should be performed * Patients aged below 18 or older than 65 would be excluded * Pregnant women would not be enrolled
References
Publications (0)
Data not yet available