Lenalidomide, Rituximab, Gemcitabine, Oxaliplatin and Dexamethasone in Relapse and Refractory DLBCL

Inclusion Criteria:

* Age 18-65 years old;
* ECOG PS 0- 2;
* Histologically confirmed diffuse large B cell lymphoma（With exception of Primary mediastinal large B cell lymphoma、Primary central nervous system lymphoma、HIV-related lymphoma),relapse or refractory,defined as:

  * relapse after standard first-line immunochemotherapy( R-CHOP or R-CHOP like)
  * SD as best response after 4 cycles or PD after 2 cycles of first-line immunochemotherapy;
* a measurable or evaluable disease at the time of enrollment(diameter ≥ 1.5cm）；
* Eligible for subsequent autologous stem cell transplantation；
* Female subjects in childbearing age, their serum or urine pregnancy test must be negative. All patients must agree to take effective contraceptive measures during the trial measures
* Expected survival ≥ 12 weeks；
* Understand and voluntarily sign an informed consent form, able to adhere to the study visit schedule and other protocol requirements

Exclusion Criteria:

* Women who are pregnant or lactating. Patients have breeding intent in 12 months or cannot take effective contraceptive measures during the trial measures；
* Uncontrollable active infection within four week. Prophylactic antibiotic, antiviral and antifungal treatment is permissible. Active hepatitis B or hepatitis C virus infection, as well as acquired, congenital immune deficiency diseases, including but not limited to HIV-infected persons；
* Used of systemic anti-tumor treatment within four weeks；
* CNS or meningeal involvement;
* Poor hepatic and/or renal function, defined as total bilirubin, ALT, AST, Cr more than two fold of upper normal level,Ccr\< 50 mL/min unless these abnormalities were related to the lymphoma;
* Poor bone-marrow reserve, defined as neutrophil count less than 1.5×10⁹/L or platelet count less than 75×10⁹/L, unless caused by bone marrow infiltration;
* New York Heart Association class III or IV cardiac failure; or Ejection fraction less than 50%;or history of following disease in past 6 months: acute coronary syndrome、acute heart failure、severe ventricular arrhythmia；
* Known sensitivity or allergy to investigational Product;
* Major surgery within three weeks;
* Presence of Grade III nervous toxicity within past two weeks;
* Active and severe infectious diseases;
* History of DVT or PE within past 12 months；
* Any potential drug abuse, medical, psychological or social conditions which may disturb this investigation and assessment;
* In any conditions which investigator considered ineligible for this study.