Clinical trial · Interventional
Positive End-expiratory Pressure (PEEP) in Predicting Fluid Responsiveness in Patients Undergoing One-lung Ventilation
The Influence of Positive End-expiratory Pressure (PEEP) in Predicting Fluid Responsiveness in Patients Undergoing One-lung Ventilation
NCT03794414CI-TRIAL-00046273completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The present study is to evaluate the effect of positive end-expiratory pressure (PEEP) in predicting fluid responsiveness in patients undergoing one-lung ventilation.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Lung Diseases | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| PEEP challenge | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- fluid responder
- description
- patients with 10% or more increase in stroke volume after fluid challenge. Both arms receive PEEP challenge.
- interventionNames
- Procedure: PEEP challenge
- type
- EXPERIMENTAL
- label
- fluid non-responder
- description
- patients with no increase or less than 10% increase in stroke volume after fluid challenge. Both arms receive PEEP challenge
- interventionNames
- Procedure: PEEP challenge
Primary outcomes (1)
- measure
- pulse pressure variation
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing lung surgery under one-lung ventilation Exclusion Criteria: * arrhythmia * moderate to severe valvular heart disease moderate to severe pericardial effusion left ventricular ejection fraction \< 40% * moderate to severe chronic obstructive lung disease * unable to insert oesophageal Doppler Monitor (ODM) probe ( esophageal stent, esophageal cancer, previous esophageal surgery, esophageal stricture, esophageal varices, pharyngeal pouch and severe coagulopathy ) * patient refusal * cannot understand the protocol * less than 50kg or over 100kg in weight
References
Publications (0)
Data not yet available
No reference posted for this study.