General Tissue Response Classification System After Chemotherapy

Inclusion Criteria:

1. The diagnosis of gastric cancer was clear，Patients with definitely clinical evidence of locally advanced disease (cT3 ⁄ 4、N-/+、M0).
2. Preoperative chemotherapy has been administered，and intended to receive surgical resection.
3. Age:less than or equal to 75 years old and more than 18 years old;
4. Without any other malignant tumor, without any serious concomitant disease.
5. Eastern Cooperative Oncology Group (ECOG) physical status score \<2, America Society of Anesthesiologist (ASA) score\<3
6. No restriction on gender or race; Informed consent has been signed by patient or entrusted agent；

Exclusion Criteria:

1. Previous history of gastric ulcer or gastric perforation;
2. Previous operation history at upper abdominal, except laparoscopic cholecystectomy;
3. Emergency operation caused by obstruction, perforation,and acute hemorrhage;
4. The patient can not tolerate the surgical treatment which caused by other serious concomitant disease, such as severe pulmonary disease, cardiac clinical function below are below level 2, pulmonary infection, moderate or severe chronic obstructive pulmonary disease (COPD), chronic bronchitis
5. Patient has severe mental illness
6. The patient and agent request to withdraw from the clinical study after signing the consent form.