Clinical trial · Observational
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
Lymphocyte T Regulatory , Th17 and NKT in Epithelial Ovarian Tumor- Prognostic Assessment and Relationship With Clinical Marker
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA. Material and methods Mononuclear cells (PBMCs) were isolated by density gradient centrifugation obtained from peripheral blood and ovarian tissue of patient suffering ovarian pathology. Patient from control group underwent surgery for unexplanied infertility. The percentage of Treg and Th17 , NKT in peripheral blood and the tissue was assessed using the flow cytometry method according to the manufacturer's instructions. The ROMA index was calculated according to the levels of HE4 and CA-125 in serum.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Ovarian Tumor | Benign Ovarian Neoplasm | ALIAS | 0.90 |
| Borderline Ovarian Tumors | Ovarian Neoplasm | PROBABILISTIC | 0.70 |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
| Unexplained Infertility | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA. | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Patient with benign ovarian tumor
- description
- 25 patients with benign ovarian tumor (cystadenoma) were admitted to IInd Department of Gynecology, Lublin Medical University, Lublin, Poland.
- interventionNames
- Other: Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- label
- Patient with borderline tumor
- description
- 11 women with borderline ovarian tumor were admitted to IInd Department of Gynecology
- interventionNames
- Other: Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- label
- Patient with ovarian cancer
- description
- 24 women with ovarian cancer were admitted to IInd Department of Gynecology
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * written informed consent * age 18-75 * ovarian tumor Exclusion Criteria: * below 18 years old * necrosis in tumor
References
Publications (1)
- DERIVEDWinkler I, Wos J, Bojarska-Junak A, Semczuk A, Rechberger T, Baranowski W, Markut-Miotla E, Tabarkiewicz J, Wolinska E, Skrzypczak M. An association of iNKT+/CD3+/CD161+ lymphocytes in ovarian cancer tissue with CA125 serum concentration. Immunobiology. 2020 Nov;225(6):152010. doi: 10.1016/j.imbio.2020.152010. Epub 2020 Aug 28. PMID 33130518