Clinical trial · Observational
Role of the Peritoneal Microenvironment in the Pathogenesis and Spread of Colorectal Carcinomatosis
NCT03777943CI-TRIAL-00080867MMTcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this project is to investigate the extent and role of mesothelial - mesenchymal transition (MMT) and cancer associated fibroblasts (CAFs) in the pathogenesis of colorectal peritoneal carcinomatosis (PC).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Peritoneal Carcinomatosis | Peritoneal Carcinomatosis | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Sampling peritoneal tissue | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Cytoreductive surgery (CRS)
- description
- In patients presenting with colorectal peritoneal carcinomatosis, peritoneal tissue will be sampled during surgery at 4 different locations.
- interventionNames
- Procedure: Sampling peritoneal tissue
Primary outcomes (1)
- measure
- Immunohistochemistry (IHC) analysis
- timeFrame
- Within 6 months after collection of the samples
- description
- Extensive IHC analysis will be performed including CD44, integrins, ICAM-1, hyaluronate, and VCAM-1 (adhesion molecules); calretinin, mesothelin, WT1, cytokeratins and E-cadherin (mesothelial markers); α-SMA, FAP and podoplanin (CAF specific markers); PDGF, VEGF and EDGF (angiogenesis related markers)
Secondary outcomes (2)
- measure
- Intra-tumoral versus peritoneal vascularity
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: • Patients presenting with colorectal peritoneal carcinomatosis Exclusion Criteria: * Pregnancy or breast feeding * Psychiatric pathology capable of affecting comprehension and judgment faculty * HIPEC (hyperthermic intraperitoneal chemotherapy) or PIPAC (pressurized intraperitoneal aerosol chemotherapy) in the past * Abdominal radiation treatment
References
Publications (0)
Data not yet available
No reference posted for this study.