Clinical trial · Observational
Evaluating Structural and Functional Changes of Brain by fMRI and DTI in Patients With Intracranial Germ Cell Tumors
Evaluating Changes of Brain Networks and White Matter Fibers by fMRI and DTI After Treatments in Patients With Germ Cell Tumors in the Basal Ganglia
NCT03771625CI-TRIAL-00039763unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Intracranial Germ Cell Tumor | Adult Intracranial Germ Cell Tumor | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- single-group studies
- description
- All the patients received chemotherapy and radiotherapy.
- interventionNames
- Radiation: radiotherapy
Primary outcomes (2)
- measure
- Changes of brain networks measured by BOLD-fMRI after treatments.
- timeFrame
- The fMRI scans are performed: (1) before treatments in one week, (2) before radiotherapy in one week, (3) after radiotherapy in one week, (4) one year after radiotherapy.
- description
- The brain networks during treatments are compared by functional connectivity.
- measure
- Changes of white matter fibers measured by DTI after treatments.
- timeFrame
- The DTI scans are performed along with the fMRI scans.
- description
- The white matter fibers damaged by tumor are evaluated by FA and MD value.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
Show eligibility criteria text
Inclusion Criteria: 1. age ≥3 years; 2. no history of brain radiotherapy; 3. no other known cause of movement and cognitive impairment; 4. no contraindications to the magnetic resonance imaging (MRI) scan; Exclusion Criteria: 1. patients can not tolerate MR scan; 2. head motion is greater than 3 mm during functional MRI scanning.
References
Publications (1)
- BACKGROUNDLiang SY, Yang TF, Chen YW, Liang ML, Chen HH, Chang KP, Shan IK, Chen YS, Wong TT. Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment. Neuro Oncol. 2013 Nov;15(11):1543-51. doi: 10.1093/neuonc/not127. Epub 2013 Oct 6. PMID 24101738