Human Leukocyte Antigen Typing and Tumor Antigen Expression Profiling

Inclusion Criteria:

1. Signed an Informed Consent Form (ICF)
2. Patients ≥ 18 years of age
3. Patients with confirmed advanced and/or metastatic solid tumors.
4. For liver cancer patients, the diagnosis must be confirmed

   * Pathological diagnosis of liver cancer based on biopsy/resection is required
   * For patients without pathological diagnosis, an imaging technique obtained by computed tomography (CT) scan or magnetic resonance imaging (MRI) is needed.
5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 0-1
6. Life expectancy \> 6 months
7. There is no limitation for prior anti-cancer treatments
8. HLA molecular phenotype positive.
9. Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST)1.1
10. At least one lesion considered accessible for biopsy unless fresh tumor tissue is being collected during a surgical procedure directed towards tumor treatment or palliative therapy or the patient has uterine cancer (including endometrial cancer or uterine carcinosarcoma) or melanoma
11. Patient has adequate pulmonary function
12. Acceptable organ and marrow function
13. Acceptable coagulation status
14. Adequate hepatic function
15. Acceptable levels of serum creatinine
16. For liver cancer patients only, Child-Pugh score of \< 6

Exclusion Criteria:

1. History of other malignancies (except for adequately treated basal or squamous cell carcinoma or carcinoma in situ) within the last 3 years
2. Patients with primary central nervous system (CNS)/brain tumors
3. Patients whose tumors have very low expression of tumor antigen targets such as kidney chromophobe, thyroid carcinoma, and prostate adenocarcinoma
4. Patients who are pregnant or are breastfeeding
5. Patients with serious autoimmune disease Note: At the discretion of the investigator, these patients may be included if their disease is well controlled without the use of immunosuppressive agents
6. Patients with prior stem cell transplantation or solid organ transplantation
7. Any condition contraindicating leukapheresis
8. Patients with any of the following cardiac conditions: uncontrolled hypertension despite optimal therapy, uncontrolled angina, ventricular arrhythmias, congestive heart failure, baseline left ventricular ejection fraction ≤ 50%, prior or current cardiomyopathy, atrial fibrillation with heart rate \> 100 bpm, unstable ischemic heart disease
9. Patients with active diverticulitis, intra-abdominal abscess, or GI obstruction
10. Patients with active pneumonitis
11. Patients with active (uncontrolled/untreated) brain metastases NOTE: Patients with a history of brain metastases may be eligible, if an imaging scan with contrast enhancement not older than 4 weeks is able to exclude the existence of currently active brain metastasis.
12. History of hypersensitivity on fludarabine (FLU), cyclophosphamide (CY), or interleukin (IL)-2
13. History of current immunodeficiency disease or prior treatment compromising immune function at the discretion of the investigator.
14. Patients with Grade 3 or Grade 4 immune-related toxicities related to checkpoint inhibitors or patients requiring corticosteroid treatment (≥ 10 mg/day prednisone or equivalent dose).
15. Patients with bleeding diathesis or coagulopathy
16. Any serious and/or unstable pre-existing medical, psychiatric disorder or other conditions that could interfere with patient's safety
17. HIV infection, active hepatitis B or C infection. History of treated hepatitis B or C is permitted if the viral load is undetectable per qPCR and/or nucleic acid testing