Icotinib as Neoadjuvant Therapy in EGFR-mutant Stage ⅢA-N2 Non-small Cell Lung Cancer

Inclusion Criteria:

* Histology or cytology confirmed Non-small Cell Lung Cancer; EGFR mutation (EGFR 19del and/or 21L858R) detected by tumor tissue biopsy of primary lesion or metastatic lesion or plasma ctDNA
* No previous anti-tumor treatment such as surgery, chemotherapy, radiotherapy or biological therapy
* Stage IIIA N2 NSCLC according to the pathological evidence of endobronchial ultrasound(EBUS) or PET-CT, the short-axis diameter of lymph node 1-2cm, and considered surgically resectable at baseline by the surgical oncologist
* Sufficient tumor histological specimens (non-cytology) for molecular marker analysis
* At least one lesion with measurable diameter and its longest diameter is large than 10 mm by CT measurement

Exclusion Criteria:

* Previous systemic anti-tumor treatment of Non-small Cell Lung Cancer, including cytotoxic drug therapy, targeted drug therapy (tyrosine kinase inhibitors or monoclonal antibodies) and experimental treatment, etc
* Previous local radiotherapy of Non-small Cell Lung Cancer
* Be allergic to any component of Icotinib tablet (Conmana)
* Other cancers within five years prior to the treatment of this study. Except for cervical carcinoma, basal cell carcinoma and bladder epithelial neoplasm (including Ta and Tis)
* Any instable systemic disease, including: active infection, high blood pressure out of control, unstable angina, onset of angina pectoris within the past 3 months, congestive heart failure, myocardial infarction, severe arrhythmia, liver, kidney or metabolic disease
* Previous interstitial lung disease, drug-induced interstitial disease, radiation pneumonia requiring hormone therapy or any active intersexual lung disease with clinical evidence
* Idiopathic pulmonary fibrosis detected by CT scan at baseline;
* Not fully controlled eye inflammation or infections, or any condition that may lead to the above eye diseases
* Human immunodeficiency virus infection
* Patients undergoing major surgery or severe trauma within 2 months prior to the first use of the experimental drug
* Patients with Small Cell Lung Cancer
* Pregnant or lactating women
* Neurological or psychiatric disorders history, including epilepsy or dementia
* Other situations not appropriate to enter the group considering by the investigators