Clinical trial · Observational
HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
A Multi-omics Study on the Human Papillomavirus Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include genome wide association study (GWAS), whole exome sequencing, analysis of transcriptomics and metabolomics. The HPV integration status is interpreted by GWAS. A comprehensive multi-omics will reveal the role of HPV integration in the molecular mechanism of tumorigenesis and prognosis of uterine cervical adenocarcinoma.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Adenocarcinoma | Cervical Adenocarcinoma | CURATED_BROADER | 0.80 |
| Genome-wide Association Study | — | UNRESOLVED | — |
| Human Papillomavirus | — | UNRESOLVED | — |
| Metabolome | — | UNRESOLVED | — |
| Prognosis | — | UNRESOLVED | — |
| Transcriptome | — | UNRESOLVED | — |
| Tumorigenesis | — | UNRESOLVED | — |
| Whole Exome Sequencing | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| A multi-omics analysis | Combination Product | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patients with HPV integration
- description
- The HPV integration status will be checked by GWAS.
- interventionNames
- Combination Product: A multi-omics analysis
- label
- Patients without HPV integration
- description
- The HPV integration status will be checked by GWAS.
- interventionNames
- Combination Product: A multi-omics analysis
Primary outcomes (1)
- measure
- Frequencies of somatic driving mutations
- timeFrame
- Two years
- description
- The differences of frequencies of somatic driving mutations will be compared between patients with and without HPV integration.
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Confirmed primary adenocarcinoma of the uterine cervix * Signed an approved informed consents * Feasible for biopsy Exclusion Criteria: * Not meeting all of the inclusion criteria
References
Publications (0)
Data not yet available