Circulating Tumor DNA for the Early Detection of HPV-positive Pelvic Cancer Relapses (CIRCA-HPV)

Inclusion Criteria:

1. 1\) Patient curatively treated within the past 3 years for:

   * a HPV-induced stage Ib3, Ic, II or III cervix cancer
   * a HPV-induced stage II or III anal canal, vagina, vulva or penis cancer
2. Patient with no evidence of any invasive tumor at inclusion (clinical and, if any, radiological exams).
3. Age ≥ 18 years
4. Availability of HPV genotyping of the treated cancer and/or archived tumor tissue available.
5. Patient who a follow-up visit is scheduled in the including center at least twice a year.
6. Patient being affiliated to the French social security.
7. Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

1. Patient presenting with active invasive tumor masses (e.g. stage IV cancer).
2. Patient deprived from ability to decide on her own or placed under the authority of a tutor.
3. Patient unable to have a regular follow up for geographical, social or psychological reasons.