Clinical trial · Observational
Longitudinal Study of Different Surgical Approaches in Chinese Patients of Uterine Cervical Cancer
Longitudinal Study of Different Surgical Approaches in Chinese Patients of Cervical Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This multi-center longitudinal study aims to compare the survival outcomes (including overall survival, progression-free survival and disease-free survival between uterine cervical patients receiving different surgical routes (vaginal, laparotomy and laparoscopy), which is the primary study objective. All clinical and pathological data would be retracted from case reviews, and all survival data would be reached by clinic, telephone and mail follow-up. This study also would analyze the impact on survival outcomes of other factors, including nerve-sparing techniques, neoadjuvant chemotherapy, neoadjuvant radiotherapy and infection of human papillomavirus. The predictive effects of different following protocol and imaging plans will be also compared. Last, the influences of surgical routes on the fertility outcomes (pregnancy and its complications) and the ovarian reserve are important secondary study objectives.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Laparoscopy | — | UNRESOLVED | — |
| Laparotomy | — | UNRESOLVED | — |
| Mortality | — | UNRESOLVED | — |
| Recurrence | — | UNRESOLVED | — |
| Survival | — | UNRESOLVED | — |
| Uterine Cervical Neoplasms | Cervical Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic radical hysterectomy | Procedure | — | UNRESOLVED |
| Laparotomic radical hysterectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Laparotomy group
- description
- Patients in this group accepted laparotomic radical hysterectomy for cervical cancer.
- interventionNames
- Procedure: Laparotomic radical hysterectomy
- label
- Laparoscopy group
- description
- Patients in this group accepted laparoscopic or robotic radical hysterectomy for cervical cancer.
- interventionNames
- Procedure: Laparoscopic radical hysterectomy
Primary outcomes (1)
- measure
- Progression-free survival
- timeFrame
- Five years
- description
- Length of time during and after the treatment of cervical cancer, that a patient lives with the disease but it does not get worse
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Pathological confirmed as uterine cervical cancer * Having definite clinical information * Having received radical hysterectomy or trachelectomy Exclusion Criteria: * Not satisfying any of the inclusion criteria
References
Publications (1)
- DERIVEDChao X, Wu M, Ma S, Tan X, Zhong S, Song X, Li L. Efficacy of different surgical approaches on survival outcomes in patients with early-stage cervical cancer: protocol for a multicentre longitudinal study in China. BMJ Open. 2020 Aug 20;10(8):e038020. doi: 10.1136/bmjopen-2020-038020. PMID 32819996