Clinical trial · Observational
Cancer Stem Cells in Acute Leukemia
NCT03735797CI-TRIAL-00102949active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Descriptive study of acute leukemia patients. Bone marrow aspirate or peripheral blood samples will be analyzed by next-generation sequencing for novel gene signatures and variations in transcriptional and epigenetic regulatory elements such as ARID5B and SALL4 variants.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Leukemia | Acute Leukemia | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bone marrow aspirate or peripheral blood sample collection | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- ARID5B polymorphism/mutation status
- timeFrame
- 5 years
- description
- Correlation of our experimentally validated Arid5b dependent transcriptional signature with primary patient samples measured by patient ARID5B expression and polymorphisms.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 1 Month
- Maximum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed or relapsed acute leukemia (AML or ALL) * Plan to undergo diagnostic bone marrow aspirate or peripheral blood if clinically indicated (i.e. WBC\>50,000 and bone marrow contraindicated) * Age 1 month to 30 years * Understand and provide informed consent (subject if\>18, legal guardian if\<18) Exclusion Criteria: * Age 0 to 4 weeks * Treatment related leukemia or leukemia secondary to MDS * Situations that would limit compliance with study requirements or ability to willingly give consent
References
Publications (0)
Data not yet available
No reference posted for this study.