Clinical trial · Interventional
Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH)
Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH): A Prospective Non-Randomized Study by the Head and Neck Oncology Group (HNOG) at the Medical University of South Carolina (MUSC)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research study is to see if it is possible to collect tissue, saliva and blood samples from patients who are having surgery and send those samples to different labs across MUSC. The researchers in these labs will collect tissue, blood and saliva samples before surgery and during surgery to see if there are any changes in the samples. They will compare the changes in the samples to the clinical outcomes. Patients will also be given surveys to evaluate patient preferences, anxiety/distress, symptom severity, support by HPV status.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood collection | Other | — | UNRESOLVED |
| Saliva collection | Other | — | UNRESOLVED |
| Surveys | Other | — | UNRESOLVED |
| Tissue collection | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (5)
- type
- EXPERIMENTAL
- label
- Caucasian, HPV positive, Non Smoking patients
- description
- Blood, tissue and saliva specimen will be collected. Surveys will be administered.
- interventionNames
- Other: Blood collection
- Other: Saliva collection
- Other: Tissue collection
- Other: Surveys
- type
- EXPERIMENTAL
- label
- Caucasian, HPV positive, Smoking patients
- description
- Blood, tissue and saliva specimen will be collected. Surveys will be administered.
- interventionNames
- Other: Blood collection
- Other: Saliva collection
- Other: Tissue collection
- Other: Surveys
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion criteria: 1. Age \> 18 years 2. Ability to sign informed consent 3. Newly diagnosed or recurrent oral cavity squamous cell carcinoma of the tongue (stage I-IVa) or oropharyngeal squamous cell carcinoma confirmed by pathology report. Patients with Unknown primary of the neck that is HPV+ are eligible. 4. Planning to undergo surgery as a part of definitive treatment Exclusion criteria: 1. Squamous cell carcinoma metastasis to node(s) of neck with unknown primary tumor site that is HPV negative. 2. Already received some treatment, such as chemotherapy, radiation, or surgery for his/her disease at another institution when presenting to MUSC. An exception is neoadjuvant PD-1 blockade. 3. History of radiation therapy, for any indication, to the head and neck region
References
Publications (0)
Data not yet available