Clinical trial · Interventional
Simultaneous Coronary Artery Evaluation and Lung Cancer CT Screening
Simultaneous Coronary Artery Evaluation and Lung Cancer Screening With a New Ultrafast-low-dose Computed Tomography Protocol: A Pilot Randomized Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cardiac computed tomography (CT) is often performed in patients who are at high risk for lung cancer in whom screening is currently recommended. This pilot randomized study will test the feasibility, safety and diagnostic ability of a novel ultra-low-dose CT protocol that allows concomitant coronary artery evaluation and lung screening. Current or former heavy smoker subjects with suspected or known coronary artery disease will be randomized to undergo CT assessment of either thoracic area only or both coronary arteries and thoracic area. Primary end-points will be the effective contrast and radiation doses.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HEAVY SMOKING | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Coronary CT assessment | Diagnostic Test | — | UNRESOLVED |
| Lung and coronary CT assessment | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Lung and coronary CT assessment
- description
- Subjects will undergo simultaneous CT assessment of both coronary arteries and thoracic area
- interventionNames
- Diagnostic Test: Lung and coronary CT assessment
- type
- ACTIVE_COMPARATOR
- label
- Coronary CT assessment
- description
- Subjects will undergo CT assessment of coronary arteries only
- interventionNames
- Diagnostic Test: Coronary CT assessment
Primary outcomes (1)
- measure
- Safety of computed tomography as measured by effective radiation dose (as measured in mSv)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Symptomatic subjects with effort-induced or typical chest pain * High probability of coronary artery disease * Known coronary artery disease * Willing to participate to the study * Informed consent to undergo CT scan Exclusion Criteria: * Contraindications to iodinated contrast such as allergies and chronic kidney failure * Any suspicion of pregnancy
References
Publications (1)
- DERIVEDGaudio C, Tanzilli A, Mei M, Moretti A, Barilla F, Varveri A, Paravati V, Tanzilli G, Ciccaglioni A, Strano S, Pellegrini M, Barillari P, Pelliccia F. Concomitant screening of coronary artery disease and lung cancer with a new ultrafast-low-dose Computed Tomography protocol: A pilot randomised trial. Sci Rep. 2019 Sep 25;9(1):13872. doi: 10.1038/s41598-019-50407-6. PMID 31554878