Clinical trial · Interventional
Neuromodulation for Hypothalamic Obesity
Deep Brain Stimulation for Hypothalamic Obesity: A Surgical & Neuroimaging Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): no participants have been able to qualify for study
Summary
Brief summary (as posted)
The balance between hunger and satiety is imperative for an individual's survival and overall health.). Without this balance, individuals can become morbidly obese or lack adequate nutrition for survival. Craniopharyngioma (CP) is a benign tumour that occurs at the base of the brain in children. Unfortunately, pediatric neurosurgeons sometimes inadvertently destroy a child's satiety centre during CP tumour removal surgery. This leaves the child with a post-operative complication: an insatiable appetite. This form of obesity is called "hypothalamic obesity". This study is designed to investigate Deep Brain Stimulation for hypothalamic obesity in n=6 young adults who have stabilized tumours.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Craniopharyngioma | Craniopharyngioma | ONTOLOGY_EXACT | 0.90 |
| Hypothalamic Obesity | — | UNRESOLVED | — |
| Metabolic Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hypothalamic Deep Brain Stimulation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Open-Label Lateral Hypothalamic DBS Stimulation
- description
- Open-label lateral hypothalamic DBS stimulation for 1 year.
- interventionNames
- Device: Hypothalamic Deep Brain Stimulation
Primary outcomes (1)
- measure
- Number of Participants With Adverse Events That Are Related to surgery and Post-Operative Side Effects
- timeFrame
- 12 months
Secondary outcomes (3)
- measure
- Body Mass Index (BMI)
- timeFrame
- 12 months
- description
- Measuring BMI(kg/m\^2) following 12 months of constant stimulation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with hypothalamic obesity following craniopharyngioma tumour removal * Treatment refractory to pharmacological interventions such as growth hormone therapy and anti-obesity medications Exclusion Criteria: * Unable to give consent or unmanaged psychiatric condition
References
Publications (5)
- BACKGROUNDLustig RH. Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment. Front Endocrinol (Lausanne). 2011 Nov 3;2:60. doi: 10.3389/fendo.2011.00060. eCollection 2011. PMID 22654817
- BACKGROUNDLustig RH. Hypothalamic obesity: causes, consequences, treatment. Pediatr Endocrinol Rev. 2008 Dec;6(2):220-7. PMID 19202508
- BACKGROUNDLustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S, Merchant TE. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab. 2003 Feb;88(2):611-6. doi: 10.1210/jc.2002-021180. PMID 12574189
- BACKGROUNDLustig RH, Rose SR, Burghen GA, Velasquez-Mieyer P, Broome DC, Smith K, Li H, Hudson MM, Heideman RL, Kun LE. Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr. 1999 Aug;135(2 Pt 1):162-8. doi: 10.1016/s0022-3476(99)70017-x. PMID 10431109
- BACKGROUNDHo AL, Sussman ES, Zhang M, Pendharkar AV, Azagury DE, Bohon C, Halpern CH. Deep Brain Stimulation for Obesity. Cureus. 2015 Mar 25;7(3):e259. doi: 10.7759/cureus.259. eCollection 2015 Mar. PMID 26180683