Clinical trial · Observational
Relationship Between Genetic Polymorphism and Postoperative Nausea and Vomiting in Chinese Han Population
Relationship Between Genetic Polymorphism and Postoperative Nausea and Vomiting Undergoing Breast Surgery With General Anesthesia in Chinese Han Population
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Postoperative nausea and vomiting ( PONV ) is one of the common complications after general anesthesia while genetic factors may play an important role in Postoperative nausea and vomiting. In this study, the investigators investigated the relationship between gene polymorphism ( such as single nucleotide polymorphism ) of the gene HTR3A ( 5-hydroxytryptamine receptor 3A ), HTR3B ( 5-hydroxytryptamine receptor 3B ), HTR3C ( 5-hydroxytryptamine receptor 3C ) and TACR1 ( tachykinin receptor 1 ) etc. with nausea and vomiting after general anesthesia. Simultaneously, the investigators explored the influencing factors of nausea and vomiting.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia, General | — | UNRESOLVED | — |
| Breast Neoplasms | Breast Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (4)
- measure
- Whether the participants occur nausea or not
- timeFrame
- Period of 0 to 6 hours after surgery
- description
- Nausea was defined as a feeling of wanting to throw up or about to throw up.
- measure
- Whether the participants occur vomiting or not
- timeFrame
- Period of 0 to 6 hours after surgery
- description
- Vomiting was defined as the discharge of the stomach contents, while retching as an involuntary attempt to vomit that did not produce stomach contents. Retching was considered as vomiting.
- measure
- Whether the participants occur nausea or not
- timeFrame
- Period of 6 to 24 hours after surgery
- description
- Nausea was defined as a feeling of wanting to throw up or about to throw up.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Undergoing breast surgery with general anesthesia * American Society of Anesthesiologists Physical Status Classifications 1-2 * No history of smoking * body mass index (BMI) \<35 kg/m2 Exclusion Criteria: * Declined to participate * Had used antiemetics, steroids, H2 antagonists, anticholinergics, antihistamines, butyrophenones, phenothiazines, metoclopramide or opioids within 24 hours * Gastroesophageal reflux, gastrointestinal obstruction or ulcer, vestibular or hearing dysfunction * Liver impairment, renal impairment, psychiatric disorder, chronic pain * Pregnant and lactating patients * Requiring postoperative patient-controlled analgesia * Requiring prophylactic use of antiemetics * Allergic to drugs related in the study * Receiving chemotherapy within one week before surgery
References
Publications (1)
- DERIVEDYan T, Su J, Zhou L, Zhang L. Polymorphisms of 5-hydroxytryptamine receptor type 3B gene and clinical characteristics for vomiting after breast surgery in chinese han female population. J Clin Pharm Ther. 2021 Aug;46(4):936-941. doi: 10.1111/jcpt.13386. Epub 2021 Feb 19. PMID 33605481