Clinical trial · Interventional
Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery
Influence of Peri-operative Opioid Analgesia on Circulating Tumor Cells in Patients Undergoing Open Colorectal Cancer Surgery - Multi-center, Randomized Clinical Trial
NCT03700411CI-TRIAL-00072060POACC-1completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Circulating Tumor Cell | — | UNRESOLVED | — |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Epidural | Drug | — | UNRESOLVED |
| Morphine | Drug | — | UNRESOLVED |
| Piritramid | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Morphine
- description
- Morphine-based perioperative analgesia
- interventionNames
- Drug: Morphine
- type
- ACTIVE_COMPARATOR
- label
- Piritramid
- description
- Piritramid-based perioperative analgesia
- interventionNames
- Drug: Piritramid
- type
- ACTIVE_COMPARATOR
- label
- Epidural
- description
- Perioperative epidural analgesia containing an opioid
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing open radical surgery for colorectal cancer * age over 18 years * signed informed consent Exclusion Criteria: * intolerance of the study drugs * history of CRC surgery * neoadjuvant therapy * contraindications to epidural analgesia * other malignancy not in permanent remission * chronic opioid medication or opioid administration within 7 days preoperatively * immunosuppressive or corticosteroid therapy * surgery within 30 days preoperatively (except minor) * chronic or acute infection
References
Publications (1)
- DERIVEDBerta E, Srovnal J, Dytrych P, Bruthans J, Ulrichova J, Prasil P, Vecera L, Gabrhelik T, Tolmaci B, Dusa J, Maca J, Mazancova M, Haiduk F, Kutej M, Ihnat P, Michalek P, Hajduch M. Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial. BMC Anesthesiol. 2023 Feb 28;23(1):64. doi: 10.1186/s12871-023-02007-1. PMID 36855089